Evidence map›Paper›PMID 32216369›Full record

ArticleBiochemistry2020

Fluorescence-Detected Conformational Changes in Duplex DNA in Open Complex Formation by

Raashi Sreenivasan, Irina A Shkel, Munish Chhabra, Amanda Drennan, Sara Heitkamp, Hao-Che Wang, Malavika A Sridevi, Dylan Plaskon, Christina McNerney, Katelyn Callies and 2 more

Abstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raashi Sreenivasan
Munish Chhabra
Amanda Drennan
Sara Heitkamp
Hao-Che Wang
Malavika A Sridevi
Dylan Plaskon
Christina McNerney
Katelyn Callies
Clare K Cimperman
M Thomas Record

Funding

Mechanisms of RNA Polymerase-Promoter and lac Repressor-Operator InteractionsR35GM118100 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RECORD, M. THOMAS · 2016 to 2020
$2.6M
NIGMS NIH HHS R35 GM118100
6 · The paper itself

Abstract

FRET (fluorescence resonance energy transfer) between far-upstream (-100) and downstream (+14) cyanine dyes (Cy3, Cy5) showed extensive bending and wrapping of λP

Indexed as

CarbocyaninesDNADNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsFluorescenceFluorescence Resonance Energy TransferFluorescent DyesKineticsNucleic Acid ConformationPromoter Regions, GeneticProtein BindingCarbocyaninescyanine dye 3cyanine dye 5DNADNA-Directed RNA PolymerasesEscherichia coli ProteinsFluorescent Dyes

Identifiers

PMID32216369
PMCPMC7269339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.