Trial reportInternational forum of allergy & rhinology2020
Reversible obstruction of the olfactory cleft: impact on olfactory perception and nasal patency.
Trial report in International forum of allergy & rhinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Reversible obstruction of the olfactory cleft: impact on olfactory perception and nasal patency.International forum of allergy & rhinology · 2020Trial
- Impact of Septoplasty on Cognitive Function.Medeniyet medical journal · 2026Article
- Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus.Clinical reviews in allergy & immunology · 2026Review
- Sinonasal symptoms in migraine without aura: results from the cross-sectional 'Migraine in Poland' study.Frontiers in neurology · 2023Article
- Olfactory Dysfunction is Associated with More Severe Clinical Course in COVID-19.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Beyond aroma: A scoping review on the impact of chronic rhinosinusitis on retronasal olfaction.Frontiers in allergy · 2022Article
- COVID-19 Anosmia: High Prevalence, Plural Neuropathogenic Mechanisms, and Scarce Neurotropism of SARS-CoV-2?Viruses · 2021Review
- Effective Connectivity in the Human Brain for Sour Taste, Retronasal Smell, and Combined Flavour.Foods (Basel, Switzerland) · 2021Article
- Ortho- and retronasal olfactory performance in rhinosurgical procedures: a longitudinal comparative study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis.Laryngoscope investigative otolaryngology · 2020Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTemporary disruption of sensory input can be studied relatively easily for vision or hearing by covering the eyes or ears. In contrast, closing the nostrils affects not only the sense of smell, but also the ability to breathe through the nose and humidify and warm inhaled air. We hypothesized that filling the olfactory cleft (OC) with dissolvable nasal dressing (foam) would temporarily block olfaction while respecting nasal airflow.
methodsIn 30 healthy volunteers, the OC was unilaterally obstructed in a back-to-front fashion. Orthonasal and retronasal olfactory function were tested before and after foam application. Ratings of odors and subjective nasal patency (SNP) were collected. Peak nasal inspiratory flow (PNIF) was used to measure nasal patency.
resultsFoam was safely applied in every case using minimal instruments. No complications were reported. Orthonasal and retronasal test results decreased significantly in overall participants (all p < 0.0008). Indicating temporary anosmia, 3 subjects reached the lowest possible score for odor-threshold testing, with corresponding drops in retronasal test scores. PNIF values before and after foam application were not significantly different (p = 0.11). SNP ratings decreased slightly, but not significantly (p = 0.052). Odor-intensity ratings dropped significantly (all p < 0.05).
conclusionThe OC can be safely obstructed with dissolvable nasal dressing, resulting in a decrease in odor-intensity and orthonasal and retronasal olfactory function test scores. This procedure may serve as a hyposmia model that maintains normal nasal airflow.
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