ArticleAngewandte Chemie (International ed. in English)2020
Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Improved Skill of Rotaxanes to Recognize Cations: A Theoretical Perspective.ACS physical chemistry Au · 2025Article
- Breaking theJournal of the American Chemical Society · 2023Article
- Site-Selective Functionalization of Unactivated Allylic C-H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene.Organic letters · 2023Article
- Continuous-Flow Divergent Lithiation of 2,3-Dihalopyridines: Deprotolithiation versus Halogen Dance.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Exploiting Coordination Effects for the Regioselective Zincation of Diazines Using TMPZnX⋅LiX (X=Cl, Br).Angewandte Chemie (International ed. in English) · 2022Article
- Continuous Flow Preparation of Benzylic Sodium Organometallics.Angewandte Chemie (International ed. in English) · 2022Article
- Sigma/pi Bonding Preferences of Solvated Alkali-Metal Cations to Ditopic Arylmethyl Anions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- (2-Ethylhexyl)sodium: A Hexane-Soluble Reagent for Br/Na-Exchanges and Directed Metalations in Continuous Flow.Angewandte Chemie (International ed. in English) · 2021Article
- Preparation and reactions of polyfunctional magnesium and zinc organometallics in organic synthesis.Chemical science · 2021Review
- Continuous Flow Sodiation of Substituted Acrylonitriles, Alkenyl Sulfides and Acrylates.Angewandte Chemie (International ed. in English) · 2021Article
- Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow.Angewandte Chemie (International ed. in English) · 2020Article
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3 authors.
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Abstract
We report the preparation of lithium-salt-free KDA (potassium diisopropylamide; 0.6 m in hexane) complexed with TMEDA (N,N,N',N'-tetramethylethylenediamine) and its use for the flow-metalation of (hetero)arenes between -78 °C and 25 °C with reaction times between 0.2 s and 24 s and a combined flow rate of 10 mL min
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