ArticleAnnals of neurology2020
A Prospective Study of Acute Blood-Based Biomarkers for Sport-Related Concussion.
Article in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07636408 (Enhancing Sleep to Improve Brain-heart Functions in People With Persistent Post-concussion Symptoms), which is not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancing Sleep to Improve Brain-heart Functions in People With Persistent Post-concussion Symptoms
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Peripheral Blood and Salivary Biomarkers of Blood-Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts.Frontiers in neurology · 2020Pooled it
- Reliable Change of Blood-Based Biomarkers Following Acute Sport-Related Concussion: A CARE Consortium Study.Sports medicine (Auckland, N.Z.) · 2026Article
- Simoa and MSD platforms show analytical discordance but comparable diagnostic performance for GFAP, NF-L, and T-tau in adolescent concussion.Scientific reports · 2026Article
- Domain-Specific Concussion Knowledge and Reporting in United States Major League Rugby Players.European journal of sport science · 2026Article
- The role of oral contraceptive use in associations of concussion history with kynurenine pathway metabolites, inflammation, and psychological symptoms in female athletes.Brain, behavior, & immunity - health · 2026Article
- Mapping the acute trajectory of sport-related concussion outcomes across symptoms, cognition, and blood biomarkers.Sports medicine and health science · 2026Review
- Effect of Obese Body Mass Index on Clinical Outcomes and Inflammatory Blood Biomarkers following Sport-Related Concussion in Collegiate Athletes and Military Cadets: Findings from the NCAA-DoD CARE Consortium.Sports medicine (Auckland, N.Z.) · 2025Article
- Objective Markers for Diagnosing Concussions: Beyond Blood Biomarkers and the Role of Real-Time Diagnostic Tools.Journal of clinical medicine · 2025Review
- Regional and Global Changes in Brain Structure 1-Year Post Pediatric "Mild" Traumatic Brain Injury.Annals of neurology · 2025Article
- Review
- Effects of Selective Head-and-Neck Cooling on Brain Injury-Related Biomarker Levels and Symptom Rating Following a Boxing Bout: Protocol for an Exploratory Randomized Trial.JMIR research protocols · 2025Article
- Efficacy of biomarkers and imaging techniques for the diagnosis of traumatic brain injury: challenges and opportunities.Molecular and cellular biochemistry · 2025Review
- Article
- Associations Between Instrumented Mouthguard-Measured Head Acceleration Events and Post-Match Biomarkers of Astroglial and Axonal Injury in Male Amateur Australian Football Players.Sports medicine (Auckland, N.Z.) · 2025Article
- Association of Traumatic Meningeal Enhancement on MRI With Clinical Recovery in Patients With Traumatic Brain Injury.Neurology · 2025Observational
- Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury.Scientific reports · 2025Article
- Plasma Biomarkers of Traumatic Brain Injury in Adolescents With Sport-Related Concussion.JAMA network open · 2024Article
- The relationship between multiple concussions and multidimensional sleep quality in collegiate-aged, active athletes.Sleep health · 2024Article
- An exploratory study on the association between blood-based biomarkers and subacute neurometabolic changes following mild traumatic brain injury.Journal of neurology · 2024Article
- Association of Blood Biomarkers of Inflammation With Acute Concussion in Collegiate Athletes and Military Service Academy Cadets.Neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveProspectively characterize changes in serum proteins following sport-related concussion and determine whether candidate biomarkers discriminate concussed athletes from controls and are associated with duration of symptoms following concussion.
methodsHigh school and collegiate athletes were enrolled between 2015 and 2018. Blood was collected at preinjury baseline and within 6 hours (early acute) and at 24 to 48 hours (late acute) following concussion in football players (n = 106), matched uninjured football players (n = 84), and non-contact-sport athletes (n = 50). Glial fibrillary acidic protein, ubiquitin c-terminal hydrolase-L1, S100 calcium binding protein B, alpha-II-spectrin breakdown product 150, interleukin 6, interleukin 1 receptor antagonist, and c-reactive protein were measured in serum. Linear models assessed changes in protein concentrations over time. Receiver operating curves quantified the discrimination of concussed athletes from controls. A Cox proportional hazard model determined whether proteins were associated with symptom recovery.
resultsAll proteins except glial fibrillary acidic protein and c-reactive protein were significantly elevated at the early acute phase postinjury relative to baseline and both control groups and discriminated concussed athletes from controls with areas under the curve of 0.68 to 0.84. The candidate biomarkers also significantly improved the discrimination of concussed athletes from noncontact controls compared to symptom severity alone. Glial fibrillary acidic protein was elevated postinjury relative to baseline in concussed athletes with a loss of consciousness or amnesia. Finally, early acute levels of interleukin 1 receptor antagonist were associated with the number of days to symptom recovery.
interpretationBrain injury and inflammatory proteins show promise as objective diagnostic biomarkers for sport-related concussion, and inflammatory markers may provide prognostic value. ANN NEUROL 2020;87:907-920.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.