ReviewJournal of neuroscience research2020
Sleep, brain development, and autism spectrum disorders: Insights from animal models.
Review in Journal of neuroscience research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 74 citations in OpenAlex.
- Histomorphometrical Analyses of the Mouse Suprachiasmatic Nucleus.Bio-protocol · 2026Article
- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
- The irreplaceable role of sleep in building long-term memories: offline integration of free cortical units and its possible implication in autism.Frontiers in human neuroscience · 2026Article
- Association Between Age-Specific Sleep Sufficiency and Autism Spectrum Disorder in U.S. Children.Journal of autism and developmental disorders · 2025Article
- Influence of Repeated Exposure to Neonatal Isoflurane on Sleep Architecture and Neuronal Delta and Theta Oscillations in Adolescent Rats.Anesthesia and analgesia · 2025Article
- The interplay between genomic copy number variants, sleep, and cognition in the general population.Translational psychiatry · 2025Article
- Autism Spectrum Disorder: From Experimental Models to Probiotic Application with a Special Focus onNutrients · 2025Review
- Animal models of autism spectrum disorder: Insights into genetic, structural and environmental models.Veterinarni medicina · 2025Review
- NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model.iScience · 2025Article
- Excitatory/Inhibitory imbalance as a mechanism linking autism and sleep problems.Current opinion in neurobiology · 2025Review
- Circadian activity and sleep architecture in autism spectrum disorder mouse model withFrontiers in sleep · 2025Article
- Developing forebrain synapses are uniquely vulnerable to sleep loss.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sex differences in sleep deficits in mice with an autism-linked Shank3 mutation.Biology of sex differences · 2024Article
- Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.Nature communications · 2024Article
- Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders.Cell & bioscience · 2024Article
- Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome.Cell reports · 2024Article
- Parental and Child Sleep: Children with Vision Impairment, Autistic Children, and Children with Comorbid Vision Impairment and Autism.Brain sciences · 2024Article
- Autism Across the Lifespan.Focus (American Psychiatric Publishing) · 2024Article
- Sleep and Autism: Current Research, Clinical Assessment, and Treatment Strategies.Focus (American Psychiatric Publishing) · 2024Article
- Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development.Neuroscience and biobehavioral reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is an evolutionarily conserved and powerful drive, although its complete functions are still unknown. One possible function of sleep is that it promotes brain development. The amount of sleep is greatest during ages when the brain is rapidly developing, and sleep has been shown to influence critical period plasticity. This supports a role for sleep in brain development and suggests that abnormal sleep in early life may lead to abnormal development. Autism spectrum disorder (ASD) is the most prevalent neurodevelopmental disorder in the United States. It is estimated that insomnia affects 44%-86% of the ASD population, predicting the severity of ASD core symptoms and associated behavioral problems. Sleep problems impact the quality of life of both ASD individuals and their caregivers, thus it is important to understand why they are so prevalent. In this review, we explore the role of sleep in early life as a causal factor in ASD. First, we review fundamental steps in mammalian sleep ontogeny and regulation and how sleep influences brain development. Next, we summarize current knowledge gained from studying sleep in animal models of ASD. Ultimately, our goal is to highlight the importance of understanding the role of sleep in brain development and the use of animal models to provide mechanistic insight into the origin of sleep problems in ASD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.