ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
Acute hematoma expansion after spontaneous intracerebral hemorrhage: risk factors and impact on long-term prognosis.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Rates and risk factors for major adverse cardiovascular and cerebrovascular events after stroke due to intracerebral hemorrhage: Systematic review and study-level meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2026Pooled it
- Reducing Inequalities in Stroke Events-Hemorrhagic Disparities (RISE-HD): a 10-Year Longitudinal Study in Florida.Journal of racial and ethnic health disparities · 2026Article
- Risk factors and predictive model for multiple organ dysfunction syndrome in acute intracerebral hemorrhage.BMC neurology · 2025Article
- Prevalence of Risk Factors in Patients With Spontaneous Intracerebral Hemorrhage in Damascus_Syria: A Retrospective Cross-Sectional Study.Health science reports · 2025Article
- Swirl sign score system: a novel and practical tool for predicting hematoma expansion risk after spontaneous intracerebral haemorrhage.The British journal of radiology · 2024Article
- Peripheral T cell immune repertoire is associated with the outcomes of acute spontaneous intracerebral hemorrhage.Frontiers in neurology · 2024Article
- Medical versus neurosurgical treatment in ICH patients: a single center experience.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Observational
- Role and mechanisms of mast cells in brain disorders.Frontiers in immunology · 2024Review
- Predictive value of hyperglycemia on prognosis in spontaneous intracerebral hemorrhage patients.Heliyon · 2023Article
- Computed tomography in acute intracerebral hemorrhage: neuroimaging predictors of hematoma expansion and outcome.Insights into imaging · 2022Review
- Article
- Efficiency of a deep learning-based artificial intelligence diagnostic system in spontaneous intracerebral hemorrhage volume measurement.BMC medical imaging · 2021Article
- Effects of clinical nursing pathway on postoperative satisfaction and quality of life of patients with subarachnoid hemorrhage.Pakistan journal of medical sciencesArticle
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHematoma expansion (HE) after intracerebral hemorrhage (ICH) is associated with short-term mortality, but its impact on long-term prognosis is still unclear. The aim of this study was to evaluate the impact of HE on long-term survival and functional status after spontaneous ICH.
methodsConsecutive patients admitted with spontaneous ICH were prospectively enrolled and followed up for a minimum of 2 years. We compared short-term (< 30 days) and long-term survival and functional status between ICH patients with HE (HE+) and those without (HE-). Main outcomes were mortality and poor outcome, defined as modified Rankin Scale ≥ 3. Secondary outcomes included recurrent ICH, admission to institutionalized care, and ischemic events (stroke, myocardial infarction, and systemic embolism).
resultsOverall, 140 patients were included (mean age 74.9 years, male 59.3%) and followed up for a mean of 2.25 years. HE+ patients (25.7%) had larger hematoma volume at admission (23.8 ml vs 15.3 ml, p < 0.05), higher NIHSS score (14.6 vs 10.5, p < 0.05) and higher cumulative mortality (59.3% vs 39.2%, p < 0.05) compared to HE- patients. Survival analysis showed that HE+ confers higher mortality and worse functional status at all time points. HE did not associate with secondary outcomes. DISCUSSION: HE translates into higher mortality and functional dependence over long-term follow-up. Strategies limiting HE might benefit long-term functional status.
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