Evidence map›Paper›PMID 32215817›Full record

ArticleMolecular neurobiology2020

Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons.

Hailong Hou, Liwei Wang, Tianyue Fu, Makaia Papasergi, David I Yule, Houhui Xia

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  14. Magnesium and Migraine.Nutrients · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hailong HouDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Liwei WangDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Tianyue FuDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Makaia PapasergiDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
David I YuleDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Houhui XiaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA. houhui_xia@urmc.rochester.edu.ORCID http://orcid.org/0000-0001-6806-7736
University of Rochester Medical Center · US

Funding

[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR01DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2002 to 2026
$9.9M
Inhibitor-2 is a positive regulator for PP1's synaptic and cognitive functionsR01MH109719 · NIMH · UNIVERSITY OF ROCHESTER · PI XIA, HOUHUI · 2016 to 2020
$1.9M
Division of Integrative Organismal Systems IOS-1457336NIDCR NIH HHS R01 DE014756NIH HHS R01 DE014756NIMH NIH HHS R01 MH109719
6 · The paper itself

Abstract

Extracellular magnesium ion ([Mg

Indexed as

AnimalsCells, CulturedCerebral CortexCyclic AMP Response Element-Binding ProteinExcitatory Amino Acid AntagonistsFemaleMagnesiumMaleNeuronsN-MethylaspartateRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSecond Messenger SystemsSignal TransductionCyclic AMP Response Element-Binding ProteinExcitatory Amino Acid AntagonistsMagnesiumN-MethylaspartateReceptors, N-Methyl-D-AspartateCREBMagnesium influxNeuronsNMDA receptorp38 MAPKSecond messenger

Identifiers

PMID32215817
PMCPMC8202957
OpenAlexW3013767292

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.