Evidence map›Paper›PMID 32215810›Full record

ArticleImmunologic research2020

A case of aberrant CD8 T cell-restricted IL-7 signaling with a Janus kinase 3 defect-associated atypical severe combined immunodeficiency.

Aaruni Khanolkar, Jeffrey D Wilks, Guorong Liu, Bridget M Simpson, Edward A Caparelli, Dawn A Kirschmann, Jenna Bergerson, Ramsay L Fuleihan

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Immunologic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aaruni KhanolkarDepartment of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA. Akhanolkar@luriechildrens.org.
Jeffrey D WilksDepartment of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Guorong LiuDepartment of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Bridget M SimpsonDepartment of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Edward A CaparelliDepartment of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Dawn A KirschmannDepartment of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Jenna BergersonDepartment of Pediatrics, Division of Allergy and Immunology, Feinberg School of Medicine, Chicago, IL, 60611, USA.
Ramsay L FuleihanDepartment of Pediatrics, Division of Allergy and Immunology, Feinberg School of Medicine, Chicago, IL, 60611, USA.
Lurie Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T

Indexed as

Cord Blood Stem Cell TransplantationCD8-Positive T-LymphocytesExome SequencingFemaleHumansInfantInfant, NewbornInterleukin-7Janus Kinase 3MutationPhenotypePhosphorylationSevere Combined ImmunodeficiencySignal TransductionSTAT5 Transcription FactorInterleukin-7JAK3 protein, humanJanus Kinase 3STAT5 Transcription FactorAtypical-SCIDCD8 T cellsIL-7IL-7RJAK3pSTAT5

Identifiers

PMID32215810
OpenAlexW3013094346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.