ArticleSurgical endoscopy2021
Endoscopic ampullectomy for non-invasive ampullary lesions: a single-center 10-year retrospective cohort study.
Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 5 citations in OpenAlex.
- Therapeutic strategies and outcomes in the management of ampullary tumours: meta-analysis.BJS open · 2026Pooled it
- Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer.International journal of clinical oncology · 2026Guideline
- Prophylactic pancreatic duct stenting to reduce the risk of post-ampullectomy pancreatitis: a comprehensive review and meta-analysis of 1858 patients.Surgical endoscopy · 2024Pooled it
- Ampullary adenomas greater than 20 mm in size have higher risk of recurrence compared to smaller lesions.Surgical endoscopy · 2026Article
- Prophylactic Closure of Mucosal Defect to Prevent Delayed Bleeding After Endoscopic Papillectomy.Canadian journal of gastroenterology & hepatology · 2026Article
- Endoscopic papillectomy of major papilla lesions: Single tertiary care center experience.Endoscopy international open · 2025Article
- Long-term Outcomes of Ampullary Adenoma According to Resected Margin Status after Endoscopic Papillectomy.Gut and liver · 2024Article
- New Method of Papillectomy May Decrease Recurrence: Anchoring Method versus Conventional Method.Journal of clinical medicine · 2024Article
- The timing of recurrence after endoscopic papillectomy.Surgical endoscopy · 2024Article
- Readmission rate and complications following biopsy of the ampulla of Vater-A retrospective data analysis.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study.World journal of gastroenterology · 2022Article
- Impact of 5-Year Endoscopic Surveillance Intervals with Biopsy following Endoscopic Papillectomy for Ampullary Adenoma.Journal of personalized medicine · 2022Article
- Efficacy and safety of endoscopic papillectomy: a multicenter, retrospective, cohort study on 227 patients.Therapeutic advances in gastroenterology · 2022Article
- Surgical ampullectomy: A comprehensive review.World journal of gastrointestinal surgery · 2021Review
- Therapeutic Outcomes and Risk Factors for Complications of Endoscopic Papillectomy: A Retrospective Analysis of a Single-Center Study.Therapeutics and clinical risk management · 2021Article
- Novel endoscopic papillectomy for reducing postoperative adverse events (with videos).World journal of gastroenterology · 2020Article
- Preliminary experience of hybrid endoscopic submucosal dissection by duodenoscope for recurrent laterally spreading papillary lesions.World journal of gastroenterology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLesions involving the ampulla of Vater have traditionally been managed by surgical resection, albeit with high rates of morbidity and mortality. Endoscopic ampullectomy is increasingly recognized as an efficacious and safer treatment option. This study aims to evaluate the safety and efficacy of endoscopic ampullectomy for non-invasive ampullary lesions in a single tertiary referral center.
methodsPatients with non-invasive ampullary lesions, with or without familial adenomatous polyposis (FAP), were identified using pathology and endoscopy databases. The study included all patients who underwent the index ampullectomy between January 2007 and January 2017. Outcome parameters included accuracy of forceps biopsies, adverse events, success of endoscopic resection, and rate of recurrence.
resultsA total of 53 patients underwent endoscopic ampullectomy over the 10-year period. Histological upstaging was seen in 37.8% of cases at ampullectomy compared to biopsy, including 5 cases (9.4%) of invasive adenocarcinoma. Adverse events occurred in 10 patients (18.9%) consisting of bleeding (11.3%), benign papillary stenosis (3.8%), acute pancreatitis (1.9%), and duodenal perforation (1.9%). Recurrence occurred in 32.7% over a median follow-up of 30 months (range 6-104 months), with the majority (18.4%) occurring at the first surveillance endoscopy. Nonetheless, 75% of recurrences were able to be cleared endoscopically. Endoscopic resection was successful in 91.1% of patients.
conclusionsEndoscopic ampullectomy is an effective and safer therapeutic modality for non-invasive ampullary lesions, in addition to being a valuable diagnostic and staging tool. Nevertheless, careful patient selection and a commitment to endoscopic follow-up are of primary importance to achieve an optimal therapeutic outcome.
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