ArticleApplied microbiology and biotechnology2020
Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134.
Article in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Cochlioquinones 1968-2024: Chemistry, Biosynthesis, and Biological Activities with Future Perspectives.Journal of fungi (Basel, Switzerland) · 2025Review
- Novel One-Step Total Synthesis ofMolecules (Basel, Switzerland) · 2025Article
- Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines.Natural products and bioprospecting · 2023Article
- Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle.International journal of molecular sciences · 2023Review
- Alkaloid diversity expansion of a talent fungusFrontiers in microbiology · 2023Article
- Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cellSynthetic and systems biotechnology · 2022Article
- Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach.Applied microbiology and biotechnology · 2022Article
- Biosynthetic Potential of the Endophytic Fungus Helotiales sp. BL73 Revealed via Compound Identification and Genome Mining.Applied and environmental microbiology · 2022Article
- Genome and Metabolome MS-Based Mining of a Marine Strain ofJournal of fungi (Basel, Switzerland) · 2021Article
- Heterocornols from the Sponge-Derived FungusMarine drugs · 2021Article
- Genome mining Streptomyces sp. KCTC 0041BP as a producer of dihydrochalcomycin.Applied microbiology and biotechnology · 2021Article
- Phytotoxic Secondary Metabolites from Fungi.Toxins · 2021Review
- Antimicrobial Benzyltetrahydroisoquinoline-Derived Alkaloids from the Leaves ofJournal of natural products · 2021Article
- Genome-Inspired Chemical Exploration of Marine FungusMarine drugs · 2020Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Polyketide-terpenoid hybrid compounds are one of the largest families of meroterpenoids, with great potential for drug development for resistant pathogens. Genome sequence analysis of secondary metabolite gene clusters of a phytopathogenic fungus, Bipolaris sorokiniana 11134, revealed a type I polyketide gene cluster, consisting of highly reducing polyketide synthase, non-reducing polyketide synthase, and adjacent prenyltransferase. MS- and UV-guided isolations led to the isolation of ten meroterpenoids, including two new compounds: 19-dehydroxyl-3-epi-arthripenoid A (1) and 12-keto-cochlioquinone A (2). The structures of 1-10 were elucidated by the analysis of NMR and high-resolution electrospray ionization mass spectroscopy data. Compounds 5-8 and 10 showed moderate activity against common Staphylococcus aureus and methicillin-resistant S. aureus, with minimum inhibitory concentration (MIC) values of 12.5-100 μg/mL. Compound 5 also exhibited activity against four clinical resistant S. aureus strains and synergistic antifungal activity against Candida albicans with MIC values of 12.5-25 μg/mL. The biosynthetic gene cluster of the isolated compounds and their putative biosynthetic pathway are also proposed. KEY POINTS: • Ten meroterpenoids were identified from B. sorokiniana, including two new compounds. • Cochlioquinone B (5) showed activity against MRSA and synergistic activity against C. albicans. • The biosynthetic gene cluster and biosynthetic pathway of meroterpenoids are proposed. • Genome mining provided a new direction to uncover the diversity of meroterpenoids.
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