Evidence map›Paper›PMID 32215680›Full record

ArticleInternational journal of colorectal disease2020

HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life.

Paul Wesselmann, Carolynne Schwarze-Zander, Christoph Boesecke, Jürgen Rockstroh, B Stoffels, Tim O Vilz, Tim R Glowka, J C Kalff, Martin W von Websky

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Paul WesselmannDepartment of Surgery, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
Carolynne Schwarze-ZanderDepartment of Medicine I, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
Christoph BoeseckeDepartment of Medicine I, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
Jürgen RockstrohDepartment of Medicine I, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
B StoffelsDepartment of Surgery, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
Tim O VilzDepartment of Surgery, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
Tim R GlowkaDepartment of Surgery, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
J C KalffDepartment of Surgery, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany.
Martin W von WebskyDepartment of Surgery, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany. martin.vonwebsky@ukbonn.de.
University Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHIV infection and concomitant HPV-associated anal lesions may significantly impact on patients' quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. MATERIAL AND

methodsFifty-two HIV+ patients with HPV-associated anal lesions were enrolled in a survey approach after undergoing routine proctologic assessment and therapy for HPV-associated anal lesions if indicated over a time span of 11 years (11/2004-11/2015). Therapy consisted of surgical ablation and topic treatment. QoL was analyzed using the SF-36 and the CECA questionnaires.

resultsFifty-two of 67 patients (77.6%) were successfully contacted and 29/52 provided full information. The mean age was 43.8 ± 12.8 years. The median follow-up from treatment to answering of the questionnaire was 34 months. Twenty-one percent (6/29) of the patients reported suffering from recurrence of condyloma acuminata, three patients from anal dysplasia (10.3%). In the SF-36, HIV+ patients did not rate their QoL as significantly different over all items after successful treatment of HPV-associated anal lesions. In the CECA questionnaire, patients with persisting HPV-associated anal lesions reported significantly higher emotional stress levels and disturbance of everyday life compared to patients who had successful treatment (71.9/100 ± 18.7 vs. 40.00/100 ± 27.4, p = 0.004). Importantly, the sexuality of patients with anal lesions was significantly impaired (59.8/100 ± 30.8 vs. 27.5/100 ± 12.2, p = 0.032).

conclusionHPV-associated anal lesions impact significantly negative on QoL in HIV+ patients. Successful treatment of HPV-associated anal lesions in HIV+ patients improved QoL. Specific questionnaires, such as CECA, seem to be more adequate than the SF-36 in this setting.

Indexed as

Neoplasm Recurrence, LocalQuality of LifeAdolescentAdultAnus NeoplasmsCarcinoma in SituCondylomata AcuminataFollow-Up StudiesHIV SeropositivityHumansMaleMiddle AgedRecurrenceSexual BehaviorStress, PsychologicalSurveys and QuestionnairesAnal intraepithelial neoplasiaCondylomaHIVHPVQuality of lifeSF-36

Identifiers

PMID32215680
PMCPMC7245587
OpenAlexW3014023399

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.