Evidence map›Paper›PMID 32215671›Full record

ArticleExperimental brain research2020

Response of the expression of oxytocin neurons to ghrelin in female mice.

Deng Pan, Kuikui Fan, Qiang Li, Haodong Liu, Penghui Li, Rihan Hai, Chenguang Du

Abstract read
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In one paragraph

Article in Experimental brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Deng PanCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Kuikui FanCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Qiang LiCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Haodong LiuCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Penghui LiCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Rihan HaiVocational and Technical College, Inner Mongolia Agricultural University, Baotou, 014109, China.
Chenguang DuCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, China. duc@imau.edu.cn.
Inner Mongolia Agricultural University · CN

Funding

National Natural Science Foundation of China 31660701
6 · The paper itself

Abstract

Ghrelin is an orexigenic agonist that acts directly on neurons in the hypothalamus, controlling appetite and energy balance. Although its role in appetite-associated neurons has been described, the relationship between peripheral ghrelin stimulation and oxytocin expression in the paraventricular nucleus is not fully understood. We evaluated the suppressive function of ghrelin in oxytocin-positive paraventricular nucleus neurons in ovariectomized C57BL/6 mice 2 h after ghrelin injection. The results showed that, in intact mice, peripheral ghrelin stimulation activated estrogen receptor alpha-expressing neurons during the estrous cycle and that agouti-related peptide mRNA expression was remarkably increased. Agouti-related peptide neuron axons co-localized with oxytocin neurons in the paraventricular nucleus. Moreover, the response of oxytocin-positive paraventricular nucleus neurons to ghrelin was suppressed in the proestrus period, while ghrelin decreased the serum concentration of estradiol in the proestrus phase. These data suggest that ghrelin may suppress oxytocin-positive neuron expression via the arcuate nucleus agouti-related peptide circuit, with the possible influence of estradiol in the murine estrous cycle. Unraveling the mechanism of ghrelin-induced oxytocin expression in the hypothalamus paraventricular nucleus broadens the horizon for ghrelin-related appetite research.

Indexed as

Agouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusEstradiolEstrogen Receptor alphaEstrous CycleFemaleGhrelinMiceMice, Inbred C57BLNeuronsOvariectomyOxytocinParaventricular Hypothalamic NucleusAgouti-Related ProteinEsr1 protein, mouseEstradiolEstrogen Receptor alphaGhrelinOxytocinArcuate nucleusEnergy regulationEstradiolParaventricular nucleus

Identifiers

PMID32215671
OpenAlexW3013727244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.