ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2020
Characteristics and outcomes of atrial fibrillation in patients without traditional risk factors: an RE-LY AF registry analysis.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- External Validation of the REACT-HF Score for Predicting Heart Failure in Patients With Atrial Fibrillation.Journal of the American Heart Association · 2025Article
- Heart-aorta-angle correlates left atrial low voltage areas formation in hypertensive atrial fibrillation patients.Quantitative imaging in medicine and surgery · 2025Article
- Challenges and Opportunities for Atrial Fibrillation Management.Cardiology discovery · 2025Review
- Article
- Prevalence of atrial fibrillation based on tertiary hospital survey in Indonesia: A smartphone-based diagnosis.Journal of arrhythmia · 2024Article
- Genetic Basis of Early Onset Atrial Fibrillation in Patients without Risk Factors.Journal of cardiovascular development and disease · 2023Article
- Types and Outcomes of Arrhythmias in a Cardiac Care Unit in Western Kenya: A Prospective Study.Global heart · 2023Article
- Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist.International journal of cardiology. Cardiovascular risk and prevention · 2022Article
- Prognosis of Atrial Fibrillation with or without Comorbidities: Analysis of Younger Adults from a Nationwide Database.Journal of clinical medicine · 2022Article
- Prediction of risk factors for recurrence of atrial fibrillation in patients with arterial hypertension.The international journal of cardiovascular imaging · 2021Article
- Ischemic Stroke in Non-Gender-Related CHAFrontiers in cardiovascular medicine · 2021Article
- Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years.PloS one · 2021Article
- Feasibility of weight loss in obese atrial fibrillation patients attending a specialist arrhythmia clinic and its impact on ablation outcomes.Journal of arrhythmia · 2020Article
- Atrial fibrillation: villain or bystander in vascular brain injury.European heart journal supplements : journal of the European Society of Cardiology · 2020Article
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Authors and funding
20 authors.
Funding
Abstract
aimsData on patient characteristics, prevalence, and outcomes of atrial fibrillation (AF) patients without traditional risk factors, often labelled 'lone AF', are sparse. METHODS AND
resultsThe RE-LY AF registry included 15 400 individuals who presented to emergency departments with AF in 47 countries. This analysis focused on patients without traditional risk factors, including age ≥60 years, hypertension, coronary artery disease, heart failure, left ventricular hypertrophy, congenital heart disease, pulmonary disease, valve heart disease, hyperthyroidism, and prior cardiac surgery. Patients without traditional risk factors were compared with age- and region-matched controls with traditional risk factors (1:3 fashion). In 796 (5%) patients, no traditional risk factors were present. However, 98% (779/796) had less-established or borderline risk factors, including borderline hypertension (130-140/80-90 mmHg; 47%), chronic kidney disease (eGFR < 60 mL/min; 57%), obesity (body mass index > 30; 19%), diabetes (5%), excessive alcohol intake (>14 units/week; 4%), and smoking (25%). Compared with patients with traditional risk factors (n = 2388), patients without traditional risk factors were more often men (74% vs. 59%, P < 0.001) had paroxysmal AF (55% vs. 37%, P < 0.001) and less AF persistence after 1 year (21% vs. 49%, P < 0.001). Furthermore, 1-year stroke occurrence rate (0.6% vs. 2.0%, P = 0.013) and heart failure hospitalizations (0.9% vs. 12.5%, P < 0.001) were lower. However, risk of AF-related re-hospitalization was similar (18% vs. 21%, P = 0.09).
conclusionAlmost all patients without traditionally defined AF risk factors have less-established or borderline risk factors. These patients have a favourable 1-year prognosis, but risk of AF-related re-hospitalization remains high. Greater emphasis should be placed on recognition and management of less-established or borderline risk factors.
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