ArticleCerebral cortex (New York, N.Y. : 1991)2020
Early Life Stress, Frontoamygdala Connectivity, and Biological Aging in Adolescence: A Longitudinal Investigation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed.
- Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.JCPP advances · 2026Article
- The relationship between childhood trauma, personality, and subjective well-being in early and late adolescence: a network analysis.Scientific reports · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally.bioRxiv : the preprint server for biology · 2025Article
- Brain age gap is associated with cognitive abilities in captive chimpanzees.Scientific reports · 2025Article
- Sexual Minority Stress: Preliminary Evidence of Accelerated Pubertal Development in Early Adolescence.Journal of adolescence · 2025Article
- Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation During Childhood and Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample.Brain structure & function · 2024Article
- Early life adversity accelerates hypothalamic drive of pubertal timing in female rats with associated enhanced acoustic startle.Hormones and behavior · 2024Article
- Incidence of mental health conditions following pediatric hospital admissions: analysis of a national database.Frontiers in pediatrics · 2024Article
- Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems.Psychological medicine · 2023Article
- The interaction of socioeconomic stress and race on telomere length in children: A systematic review and meta-analysis.SSM - population health · 2023Article
- Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer's disease and/or major depressive disorder.Scientific reports · 2023Article
- Gender diversity associated with patterns of brain activation seen in populations that experience childhood stress.Frontiers in integrative neuroscience · 2023Article
- Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex.The European journal of neuroscience · 2023Article
- Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.The American psychologist · 2022Article
- Early life stress, systemic inflammation, and neural correlates of implicit emotion regulation in adolescents.Brain, behavior, and immunity · 2022Article
- Does pubertal stage mediate the association between family environment and structure and function of the amygdala-mPFC circuit? A replication study of the longitudinal ABCD cohort.Developmental cognitive neuroscience · 2022Article
- Prospective longitudinal associations between harsh parenting and corticolimbic function during adolescence.Development and psychopathology · 2022Article
- Experimental evidence for a child-to-adolescent switch in human amygdala-prefrontal cortex communication: A cross-sectional pilot study.Developmental science · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Early life stress (ELS) may accelerate frontoamygdala development related to socioemotional processing, serving as a potential source of resilience. Whether this circuit is associated with other proposed measures of accelerated development is unknown. In a sample of young adolescents, we examined the relations among ELS, frontoamygdala circuitry during viewing of emotional faces, cellular aging as measured by telomere shortening, and pubertal tempo. We found that greater cumulative severity of ELS was associated with stronger negative coupling between bilateral centromedial amygdala and the ventromedial prefrontal cortex, a pattern that may reflect more mature connectivity. More negative frontoamygdala coupling (for distinct amygdala subdivisions) was associated with slower telomere shortening and pubertal tempo over 2 years. These potentially protective associations of negative frontoamygdala connectivity were most pronounced in adolescents who had been exposed to higher ELS. Our findings provide support for the formulation that ELS accelerates maturation of frontoamygdala connectivity and provide novel evidence that this neural circuitry confers protection against accelerated biological aging, particularly for adolescents who have experienced higher ELS. Although negative frontoamygdala connectivity may be an adaptation to ELS, frontoamygdala connectivity, cellular aging, and pubertal tempo do not appear to be measures of the same developmental process.
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