ArticleCardiovascular research2021
The effects of sepsis on endothelium and clinical implications.
Article in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
183 citing papers in PubMed, 1 synthesis or guideline pooled it, 289 citations in OpenAlex.
- Mechanism-informed diagnostic accuracy of blood biomarkers for sepsis-associated encephalopathy: a systematic review and Bayesian diagnostic network meta-analysis.Frontiers in molecular neuroscience · 2026Pooled it
- Early passive mobilization increases vascular reactivity response in critical patients with sepsis: a quasi-experimental study.Revista Brasileira de terapia intensivaTrial
- Continuous renal replacement therapy attenuates endothelial injury biomarkers in pediatric sepsis: a prospective cohort study.Renal failure · 2026Observational
- Plasma Citrulline as a Biomarker in Critical Illness: A Structured Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Endothelial biomarkers predict kidney and cardiovascular outcomes after acute kidney injury.Clinical kidney journal · 2026Article
- Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review).International journal of molecular medicine · 2026Review
- Early Renal Perfusion Scintigraphy Is Associated with Mortality in Experimental Sepsis: A Multimodal Study Integrating Imaging, Survival, and Biomarker Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Early Evolution of Sepsis-Associated Coagulopathy and Its Association with Therapeutic Exposures: A Prospective Longitudinal Cohort Study.Journal of clinical medicine · 2026Article
- Incidence and risk factors for retinopathy of prematurity: A hospital-based study in Iran.Eye (London, England) · 2026Article
- Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock.EBioMedicine · 2026Observational
- Klebsiella pneumoniae inhibits vasodilation through capsule and T6SS-dependent pathways.Nature microbiology · 2026Article
- TRPV4/IP3R-1-mediated endothelial pyroptosis drives pulmonary microvascular endothelial permeability in endotoxin-induced acute lung injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Sepsis-Related Coronary Endarteritis With Multiple Coronary Artery Thrombi and Acute Myocardial Infarction.Pathology international · 2026Article
- Impact of altered HDL2b/HDL3 ratio on the function of innate immune cells in sepsis.Lipids in health and disease · 2026Article
- Plasma antioxidant capacity as a predictor of mortality in critically ill patients.Critical care (London, England) · 2026Observational
- Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis.MicrobiologyOpen · 2026Review
- Phosphorylated toll-like receptor 4 defines a high-risk sepsis endotype.Critical care (London, England) · 2026Article
- From Glycocalyx Shedding to Microvascular Collapse in Sepsis: Endothelial Pathophysiology, Organ Dysfunction, and Mechanistic Biomarkers.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Inter-Organ Communication Networks in Systemic Physiology: Glucocorticoid Receptor α as a Central Integrator of Homeostasis.International journal of molecular sciences · 2026Review
- Baseline Interleukin-6 in Sepsis: Mortality Risk Stratification and Survival Analysis in a Prospective Cohort.Biomedicines · 2026Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
abstractSepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an overwhelming host response to infection resulting in organ failure. The endothelium is an active contributor to sepsis and as such represents a major target for therapy. During sepsis, endothelial cells amplify the immune response and activate the coagulation system. They are both a target and source of inflammation and serve as a link between local and systemic immune responses. In response to cytokines produced by immune cells, the endothelium expresses adhesion molecules and produces vasoactive compounds, inflammatory cytokines, and chemoattractants, thus switching from an anticoagulant to procoagulant state. These responses contribute to local control of infection, but systemic activation can lead to microvascular thrombosis, capillary permeability, hypotension, tissue hypoxia, and ultimately tissue damage. This review focuses on the role of the endothelium in leucocyte adhesion and transmigration as well as production of reactive oxygen and nitrogen species, microRNAs and cytokines, formation of signalling microparticles, and disseminated intravascular coagulation. We also discuss alterations in endothelial permeability and apoptosis. Finally, we review the diagnostic potential of endothelial markers and endothelial pathways as therapeutic targets for this devastating disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.