ArticleJACC. Basic to translational science2020
Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity.
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Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction.JACC. Heart failure · 2025Trial
- Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.JAMA cardiology · 2025Trial
- Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction.Circulation · 2026Article
- Knowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force.Pulmonary circulation · 2026Article
- Rationale and Design of the HeartShare/AMP-HF Deep Phenotyping Study to Improve Understanding of Heart Failure With Preserved Ejection Fraction.JACC. Heart failure · 2025Review
- Associations between muscle quality index and cardiac function in older adults with sarcopenia and obesity.Aging clinical and experimental research · 2025Article
- Insights Into the Role of Obesity in Heart Failure With Preserved Ejection Fraction: Pathophysiology and Management.The Canadian journal of cardiology · 2025Review
- Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.Physiological reports · 2025Article
- Long-term Changes in Body Composition and Exercise Capacity Following Calorie Restriction and Exercise Training in Older Patients with Obesity and Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure · 2025Article
- Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF.JACC. Basic to translational science · 2024Article
- Article
- Identifying the Mechanisms of a Peripherally Limited Exercise Phenotype in Patients With Heart Failure With Preserved Ejection Fraction.Circulation. Heart failure · 2024Article
- α-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction.The Journal of physiology · 2024Article
- Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure.Experimental physiology · 2024Review
- Clinical phenogroup diversity and multiplicity: Impact on mechanisms of exercise intolerance in heart failure with preserved ejection fraction.European journal of heart failure · 2024Article
- Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF.Circulation. Heart failure · 2023Article
- Evidence of impaired functional sympatholysis in patients with heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2023Article
- Obesity, Preserved Ejection Fraction Heart Failure, and Left Ventricular Remodeling.Journal of clinical medicine · 2023Review
- Nonpharmacological Strategies in Heart Failure with Preserved Ejection Fraction.Cardiology clinics · 2022Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Payman ZamaniDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Elizabeth A ProtoDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Jeremy A MazurekDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Stuart B PrennerDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Kenneth B MarguliesDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Raymond R TownsendDivision of Nephrology/Hypertension, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Daniel P KellyDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Zoltan AranyDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
David C PooleDepartments of Kinesiology, Anatomy, and Physiology, Kansas State University, Manhattan, Kansas.
Peter D WagnerDivision of Pulmonary Medicine, University of California-San Diego, San Diego, California.
Julio A ChirinosDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Hospital of the University of Pennsylvania · USKansas State University · USUniversity of California, San Diego · USUniversity of Pennsylvania · US
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MSubclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4MUnderstanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7MREGULATION OF FATTY ACID OXIDATION DURING CARDIAC GROWTHR01HL058493 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1998 to 2024
$10.6MMolecular Control of Muscle Fuel MetabolismR01DK045416 · NIDDK · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1996 to 2020
$8.1MProbing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1MDetyrosinated microtubules in cardiomyocyte mechanicsR01HL133080 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Benjamin Lears Prosser · 2016 to 2026
$4.7MVASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BPR01HL104106 · NHLBI · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G, FARQUHAR, WILLIAM B · 2011 to 2021
$4.5MEfficacy of Potassium Nitrate in Heart Failure with Preserved Ejection FractionR01HL121510 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2019
$3.1MMid Atlantic Heart Failure NetworkU10HL110338 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, THOMAS P., MARGULIES, KENNETH BER · 2012 to 2018
$2.4MCardiovascular Risk after Preeclampsia - The CRISP studyR56HL136730 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LEVINE, LISA DANIELLE · 2018 to 2018
$740kHFpEF: more than just the heart - Why the mitochondria and capillaries matterK23HL130551 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ZAMANI, PAYMAN · 2016 to 2019
$699kNCATS NIH HHS UL1 TR001878NHLBI NIH HHS K23 HL130551NHLBI NIH HHS P01 HL094307NHLBI NIH HHS R01 HL058493NHLBI NIH HHS R01 HL104106NHLBI NIH HHS R01 HL121510NHLBI NIH HHS R01 HL128349NHLBI NIH HHS R01 HL133080NHLBI NIH HHS R03 HL146874NHLBI NIH HHS R56 HL136730NHLBI NIH HHS R61 HL146390NHLBI NIH HHS U10 HL110338NIA NIH HHS R01 AG058969NIDDK NIH HHS R01 DK045416
Abstract
The aim of this study was to determine the arteriovenous oxygen content difference (ΔAVo
Indexed as
adiposityaerobic capacityCO, cardiac outputDEXA, dual-energy x-ray absorptiometryDmO2, skeletal muscle diffusional conductance for oxygenexerciseFIo2, fraction of inspired oxygenHFpEFHFpEF, heart failure with preserved ejection fractionMVC, maximal voluntary contraction forceNT-proBNP, N-terminal pro–brain natriuretic peptideoxygen transportPo2, partial pressure of oxygenVo2, oxygen consumptionΔAVo2, arteriovenous oxygen content difference
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.