ArticleInternational journal of cardiology. Heart & vasculature2020
Clinical characteristics and prognostic factors in elderly patients with chronic heart failure -A report from the CHART-2 study.
Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Performance of Prognostic Risk Scores in Elderly Chinese Patients with Heart Failure.Clinical interventions in aging · 2021Pooled it
- Diet and the gut microbiota profiles in individuals at risk of chronic heart failure - A review on the Asian population.Asia Pacific journal of clinical nutrition · 2025Review
- Determination of Peak Oxygen Uptake in Patients with Acute Myocardial Infarction: The Role of Arterial Stiffness in Cardio-Vascular-Skeletal Muscle Coupling.Journal of clinical medicine · 2023Article
- Aetiology of chronic heart failure in patients from a super-aged society: the KUNIUMI registry chronic cohort.ESC heart failure · 2023Observational
- Association of serum N-terminal pro-brain natriuretic peptide levels with survival and renal outcomes among elderly patients with acute kidney injury in chronic heart failure.Frontiers in cardiovascular medicine · 2023Article
- Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan.Diabetes, obesity & metabolism · 2022Review
- Burden of Repeated Hospitalizations on Patients with Heart Failure: An Analysis of Administrative and Claims Data in Japan.Drugs - real world outcomes · 2022Article
- The virtual patient - Estimating the health utility of aspirin in simulated populations.International journal of cardiology. Heart & vasculature · 2021Article
- Inflammation-based assessment for the risk stratification of mortality in patients with heart failure.Scientific reports · 2021Observational
- Regional Disparities in Adherence to Guidelines for the Treatment of Chronic Heart Failure.Internal medicine (Tokyo, Japan) · 2021Article
- Mid-Term Prognosis After Landiolol Treatment in Atrial Fibrillation/Atrial Flutter Patients With Chronic Heart Failure - A Prospective Observational Survey (AF-CHF Landiolol Survey).Circulation reports · 2020Article
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Authors and funding
18 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince most of the randomized clinical trials for heart failure (HF) were designed to exclude elderly patients, limited data are available on their clinical characteristics, prognosis, and prognostic factors.
methodsWe compared clinical characteristics, prognosis, and prognostic factors among Stage C/D HF patients in our CHART-2 Study (N = 4876, mean 69 years, women 32%, 6.3-year follow-up) by age (G1, ≤64 years, N = 1521; G2, 65-74 years, N = 1510; and G3, ≥75 years, N = 1845).
resultsFrom G1 to G3, the prevalence of women, left ventricular ejection fraction (LVEF) and plasma levels of B-type natriuretic peptide (BNP) increased (all P < 0.001). Similarly, 5-year mortality increased (9.9, 17.3 to 39.9%, P < 0.001) along with a decrease in proportion of cardiovascular death and an increase in non-cardiovascular death in both sexes. While all-cause and cardiovascular mortality was comparable between the sexes, women had significantly lower incidence of non-cardiovascular death than men in G2 and G3, which was attributable to the higher incidence of cancer death and pneumonia death in men than in women. Although NYHA functional class III-IV, chronic kidney disease, cancer, LVEF, and BNP had significant impacts on all-cause death in all groups, their impacts were less evident in G3 as compared with G1.
conclusionsThe elderly HF patients, as compared with younger HF patients, were characterized by more severe clinical background, increased proportion of non-cardiovascular death and worse prognosis with different impacts of prognostic factors across the age groups.
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