ArticleScience China. Chemistry2012
Improved synthesis of rupintrivir.
Article in Science China. Chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.Journal of medicinal chemistry · 2023Article
- Easy access to α-ketoamides as SARS-CoV-2 and MERS MEuropean journal of medicinal chemistry · 2022Article
- Controllable synthesis and electrocatalytic applications of atomically precise gold nanoclusters.Nanoscale advances · 2021Review
- Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.Bioorganic & medicinal chemistry letters · 2018Article
- Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.Antiviral research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
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Registered trials
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