ArticleMicrofluidics and nanofluidics2017
From single-molecule detection to next-generation sequencing: microfluidic droplets for high-throughput nucleic acid analysis.
Article in Microfluidics and nanofluidics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Single-Molecule Microfluidics for Membrane Protein Biophysics.The Journal of membrane biology · 2026Review
- Metabarcoding Analysis of Microorganisms Inside Household Washing Machines in Shanghai, China.Microorganisms · 2024Article
- The Application of Hybridization Chain Reaction in the Detection of Foodborne Pathogens.Foods (Basel, Switzerland) · 2023Review
- Formation of double emulsion micro-droplets in a microfluidic device using a partially hydrophilic-hydrophobic surface.RSC advances · 2021Article
- Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Plug-in tubes allow tunable oil removal, droplet packing, and reaction incubation for time-controlled droplet-based assays.Biomicrofluidics · 2021Article
- Mixing characterization of binary-coalesced droplets in microchannels using deep neural network.Biomicrofluidics · 2020Article
- Heat and pressure-resistant room temperature irreversible sealing of hybrid PDMS-thermoplastic microfluidic devicesRSC advances · 2020Article
- Rapid generation of chemical combinations on a magnetic digital microfluidic array.RSC advances · 2019Article
- High-Precision Stereolithography of Biomicrofluidic Devices.Advanced materials technologies · 2019Article
- Microfluidic device for real-time formulation of reagents and their subsequent encapsulation into double emulsions.Scientific reports · 2018Article
- Trapping a moving droplet train by bubble guidance in microfluidic networks.RSC advances · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Droplet-based microfluidic technologies have proved themselves to be of significant utility in the performance of high-throughput chemical and biological experiments. By encapsulating and isolating reagents within femtoliter-nanoliter droplet, millions of (bio) chemical reactions can be processed in a parallel fashion and on ultra-short timescales. Recent applications of such technologies to genetic analysis have suggested significant utility in low-cost, efficient and rapid workflows for DNA amplification, rare mutation detection, antibody screening and next-generation sequencing. To this end, we describe and highlight some of the most interesting recent developments and applications of droplet-based microfluidics in the broad area of nucleic acid analysis. In addition, we also present a cursory description of some of the most essential functional components, which allow the creation of integrated and complex workflows based on flowing streams of droplets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.