ArticleMediators of inflammation2020
Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice.
Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed.
- Chronic alcohol exposure contributes to postoperative cognitive dysfunction via NR2B upregulation in the hippocampus of adult mice.Translational psychiatry · 2026Article
- Methylene blue reduces postoperative delirium in mice through neuroinflammation suppression and blood-brain barrier repair.Scientific reports · 2025Article
- Preventive Effect of Epigallocatechin-3-Gallate on Postoperative Cognitive Dysfunction in Aged Rats via Modulation of Microglial Differentiation: An Experimental Animal Study.International journal of molecular sciences · 2025Article
- Article
- Surgery induces neurocognitive disorder via neuroinflammation and glymphatic dysfunction in middle-aged mice with brain lymphatic drainage impairment.Frontiers in neuroscience · 2024Article
- Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- The Role of Microglia in Perioperative Neurocognitive Disorders.Frontiers in cellular neuroscience · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients. Numerous studies have demonstrated that multiple surgery/anesthesia during the neurodevelopmental period affects cognitive function, whereas a single anesthesia/surgery rarely causes cognitive dysfunction in adults. However, whether adults who undergo multiple anesthesia/surgery over a short period will experience cognitive dysfunction remains unclear. In this study, central nervous system inflammation and changes in cholinergic markers were investigated in adult mice subjected to multiple laparotomy procedures over a short period of time. The results showed that despite the increased expression of IL-6 and TNF-
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Registered trials
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