Observational studyVascular health and risk management2020
Prevalence and Outcomes of Thrombophilia in Patients with Acute Pulmonary Embolism.
Observational study in Vascular health and risk management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Evaluation of AT in acute pulmonary embolism with pleural effusion.Biomarkers in medicine · 2024Article
- Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism.Thrombosis and haemostasis · 2023Article
- Homozygous factor V leiden mutation: Rare etiology of pulmonary embolism.Annals of medicine and surgery (2012) · 2022Article
- Pulmonary Embolism in Women: A Systematic Review of the Current Literature.Journal of cardiovascular development and disease · 2022Review
- Osteonecrosis of the Jaws in Patients with Hereditary Thrombophilia/Hypofibrinolysis-From Pathophysiology to Therapeutic Implications.International journal of molecular sciences · 2022Review
- The Phantom of the Atrium: A Case Report of a Ghosting Thrombus.Journal of cardiovascular echographyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to study the prevalence and outcomes of thrombophilia in acute pulmonary embolism.
methodsA retrospective observational study was conducted to include patients with a radiologically confirmed diagnosis of PE screened for thrombophilia from May 2011 to February 2015. Data included patients' demographics; clinical presentation, risk factors, laboratory investigations, management, and outcome were analyzed and compared in patients with and without thrombophilia.
resultsA total of 227 cases of PE were included in the study, of which 108 (47.6%) had thrombophilia. The most frequent coagulopathic abnormality included deficiency of protein S, protein C, and antithrombin III and hyperhomocysteinemia. Only seven out of 79 patients were found to have factor V Leiden. PE patients diagnosed with thrombophilia were 10 years younger in age and peaked in the age range 30-39 years. Prior history of DVT (
conclusionDeficiencies of protein S, protein C, and antithrombin III are the leading causes of thrombophilic defects. Patients with hereditary thrombophilia are at increased risk of acute PE, particularly among young individuals. Therefore, early detection of thrombophilic defects together with other unprovoked risk factors could reduce the risk of recurrent VTE.
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