Evidence map›Paper›PMID 32214332›Full record

ArticlePloS one2020

Profile of congenital heart disease in infants born following exposure to preeclampsia.

Christopher S Yilgwan, Victor C Pam, Olukemi O Ige, Williams N Golit, Stephen Anzaku, Godwin E Imade, Gavou Yilgwan, Josiah T Mutihir, Atiene S Sagay, Augustine Odili and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Maternal Immune Activation: Implications for Congenital Heart Defects.Clinical reviews in allergy & immunology · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Preeclampsia and Cardiovascular Risk for Offspring.Journal of clinical medicine · 2021
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Christopher S YilgwanDepartment of Paediatrics, University of Jos, Jos, Nigeria.ORCID 0000-0003-4741-7009
Victor C PamDepartment of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria.
Olukemi O IgeDepartment of Paediatrics, University of Jos, Jos, Nigeria.
Williams N GolitDepartment of Obstetrics and Gynaecology, Plateau Specialist Hospital, Jos, Nigeria.
Stephen AnzakuDepartment of Obstetrics and Gynaecology, Bingham University, Karu LGA, Nigeria.
Godwin E ImadeDepartment of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria.
Gavou YilgwanDepartment of Human Physiology, University of Jos, Jos, Nigeria.
Josiah T MutihirDepartment of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria.
Atiene S SagayDepartment of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria.
Augustine OdiliDepartment of Internal Medicine, University of Abuja, Abuja, Nigeria.
Ayuba I ZoakahDepartment of Internal Medicine, University of Abuja, Abuja, Nigeria.
Fidelia Bode-ThomasDepartment of Paediatrics, University of Jos, Jos, Nigeria.
Melissa A SimonDepartment of Community Medicine, University of Jos, Jos, Nigeria.
University of Jos · NGUniversity of Abuja · NGBingham University · NGNorthwestern University · US

Funding

Support of Training and Mentoring in Nigeria for Academics (STAMINA)D43TW010130 · FIC · UNIVERSITY OF JOS · PI SAGAY, ATIENE SOLOMON · 2015 to 2019
$3.2M
FIC NIH HHS D43 TW010130
6 · The paper itself

Abstract

backgroundEvents in pregnancy play an important role in predisposing the newborn to the risk of developing CHD. This study evaluated the association between maternal preeclampsia and her offspring risk of CHD.

methodsThis is a cohort study of 90 sex-matched neonates (45 each born to women with preeclampsia and normal pregnancy) in Jos, Nigeria. Anthropometry was taken shortly after delivery using standard protocols. Echocardiography was performed within 24 hours of life and repeated 7 and 28 days later. SPSS version 25 was used in all analyses. Statistical significance was set at p<0.05.

resultsCongenital heart disease (CHD) was observed in 27 (30.0%) of newborns of women with preeclampsia compared with 11 (12.1%) of newborns without preeclampsia (p<0.001) at the end of 7 days and in 19 (21.1%) of newborns of women with preeclampsia and 3 (3.3%) of newborns of women without preeclampsia by the end of the 4th week of life (p<0.001). Overall, ASD (4 newborns), PDA (21 newborns), patent foramen ovale (14 newborns) and VSD (2 newborns) were the prevalent lesions found among all the newborns studied in the first week of life. Isolated atrial and ventricular septal defects were seen in 4 (4.4%) of the newborns of women with preeclampsia. Being the infant of a woman with preeclampsia was associated with about 8-fold increased risk of having CHD (OR = 7.9, 95% CI = 2.5-24.9, p<0.001).

conclusionCHD may be more common in newborns of women with preeclampsia underscoring the need for fetal and newborn screening for CHD in women with preeclampsia so as to improve their infant's well being.

Indexed as

Heart Defects, CongenitalPre-EclampsiaAdultFemaleHumansInfantInfant, NewbornMalePregnancyRisk Assessment

Identifiers

PMID32214332
PMCPMC7098553
OpenAlexW3013782216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.