Evidence map›Paper›PMID 32214253›Full record

ReviewNature2020

Dietary modifications for enhanced cancer therapy.

Naama Kanarek, Boryana Petrova, David M Sabatini

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 3 pooled it
31.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 3 syntheses or guidelines pooled it, 414 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Article
  5. Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026
    Review
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144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Naama KanarekDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA. naama.kanarek@childrens.harvard.edu.
Boryana PetrovaDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.
David M SabatiniBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1446-7256
Broad Institute · USBoston Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumours depend on nutrients supplied by the host for their growth and survival. Modifications to the host's diet can change nutrient availability in the tumour microenvironment, which might represent a promising strategy for inhibiting tumour growth. Dietary modifications can limit tumour-specific nutritional requirements, alter certain nutrients that target the metabolic vulnerabilities of the tumour, or enhance the cytotoxicity of anti-cancer drugs. Recent reports have suggested that modification of several nutrients in the diet can alter the efficacy of cancer therapies, and some of the newest developments in this quickly expanding field are reviewed here. The results discussed indicate that the dietary habits and nutritional state of a patient must be taken into account during cancer research and therapy.

Indexed as

DietNutritional StatusAmino AcidsAnimalsDietary SupplementsFastingFatty AcidsFolic AcidFructoseGlucoseHumansNeoplasmsAmino AcidsFatty AcidsFolic AcidFructoseGlucose

Identifiers

PMID32214253
OpenAlexW3013536588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.