ArticleScientific reports2020
Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Attenuated and delayed neural activity in cortical microcircuitry of monocular processing and binocular interactions in human amblyopia.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A selection and targeting framework of cortical locations for line-scanning fMRI.Human brain mapping · 2023Article
- Cortical depth profiles of auditory and visual 7 T functional MRI responses in human superior temporal areas.Human brain mapping · 2023Article
- Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex.Human brain mapping · 2023Article
- Layer-specific, retinotopically-diffuse modulation in human visual cortex in response to viewing emotionally expressive faces.Nature communications · 2022Article
- Non-Neural Factors Influencing BOLD Response Magnitudes within Individual Subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mapping of whole-cerebrum resting-state networks using ultra-high resolution acquisition protocols.Human brain mapping · 2022Article
- Laminar functional magnetic resonance imaging in vision research.Frontiers in neuroscience · 2022Review
- Sensitivity limitations of high-resolution perfusion-based human fMRI at 7 Tesla.Magnetic resonance imaging · 2021Article
- Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response.Progress in neurobiology · 2021Review
- Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex.Progress in neurobiology · 2021Article
- Validating Linear Systems Analysis for Laminar fMRI: Temporal Additivity for Stimulus Duration Manipulations.Brain topography · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
A fundamental assumption of nearly all functional magnetic resonance imaging (fMRI) analyses is that the relationship between local neuronal activity and the blood oxygenation level dependent (BOLD) signal can be described as following linear systems theory. With the advent of ultra-high field (7T and higher) MRI scanners, it has become possible to perform sub-millimeter resolution fMRI in humans. A novel and promising application of sub-millimeter fMRI is measuring responses across cortical depth, i.e. laminar imaging. However, the cortical vasculature and associated directional blood pooling towards the pial surface strongly influence the cortical depth-dependent BOLD signal, particularly for gradient-echo BOLD. This directional pooling may potentially affect BOLD linearity across cortical depth. Here we assess whether the amplitude scaling assumption for linear systems theory holds across cortical depth. For this, we use stimuli with different luminance contrasts to elicit different BOLD response amplitudes. We find that BOLD amplitude across cortical depth scales with luminance contrast, and that this scaling is identical across cortical depth. Although nonlinearities may be present for different stimulus configurations and acquisition protocols, our results suggest that the amplitude scaling assumption for linear systems theory across cortical depth holds for luminance contrast manipulations in sub-millimeter laminar BOLD fMRI.
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