ArticleScientific reports2020
Robot-Driven Locomotor Perturbations Reveal Synergy-Mediated, Context-Dependent Feedforward and Feedback Mechanisms of Adaptation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A randomized controlled trial on the effects induced by robot-assisted and usual-care rehabilitation on upper limb muscle synergies in post-stroke subjects.Scientific reports · 2021Trial
- Age-related differences in whole-body muscle synergies during overarm throwing in children.Scientific reports · 2026Article
- Adaptation-dependent modulation of coordinated muscle activities in human gait adaptation as revealed by tensor decomposition.iScience · 2026Article
- Neurophysiological effects of partial gravity on bimanual control: a parabolic flight study.NPJ microgravity · 2026Article
- A physiologically inspired hybrid CPG/Reflex controller for cycling simulations that generalizes to walking.PLoS computational biology · 2025Article
- Quantifying the diverse contributions of hierarchical muscle interactions to motor function.iScience · 2025Article
- Investigation of adaptive muscle synergy modulated motor responses to grasping perturbations.Scientific reports · 2024Article
- Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies.Journal of neurophysiology · 2024Article
- Article
- Data Fusion-Based Musculoskeletal Synergies in the Grasping Hand.Sensors (Basel, Switzerland) · 2022Article
- Detecting task-relevant spatiotemporal modules and their relation to motor adaptation.PloS one · 2022Article
- Modulation of Muscle Synergies in Lower-Limb Muscles Associated With Split-Belt Locomotor Adaptation.Frontiers in human neuroscience · 2022Article
- Forward and backward walking share the same motor modules and locomotor adaptation strategies.Heliyon · 2021Article
- Converging Robotic Technologies in Targeted Neural Rehabilitation: A Review of Emerging Solutions and Challenges.Sensors (Basel, Switzerland) · 2021Review
- Neuromechanical Biomarkers for Robotic Neurorehabilitation.Frontiers in neurorobotics · 2021Review
- Characterization of the Adaptation to Visuomotor Rotations in the Muscle Synergies Space.Frontiers in bioengineering and biotechnology · 2020Article
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Authors and funding
6 authors.
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Abstract
Humans respond to mechanical perturbations that affect their gait by changing their motor control strategy. Previous work indicates that adaptation during gait is context dependent, and perturbations altering long-term stability are compensated for even at the cost of higher energy expenditure. However, it is unclear if gait adaptation is driven by unilateral or bilateral mechanisms, and what the roles of feedback and feedforward control are in the generation of compensatory responses. Here, we used a robot-based adaptation paradigm to investigate if feedback/feedforward and unilateral/bilateral contributions to locomotor adaptation are also context dependent in healthy adults. A robot was used to induce two opposite unilateral mechanical perturbations affecting the step length over multiple gait cycles. Electromyographic signals were collected and analyzed to determine how muscle synergies change in response to perturbations. The results unraveled different unilateral modulation dynamics of the muscle-synergy activations during adaptation, characterized by the combination of a slow-progressive feedforward process and a fast-reactive feedback-driven process. The relative unilateral contributions of the two processes to motor-output adjustments, however, depended on which perturbation was delivered. Overall, these observations provide evidence that, in humans, both descending and afferent drives project onto the same spinal interneuronal networks that encode locomotor muscle synergies.
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