ArticleScientific reports2020
Microbiota and metabolome responses in the cecum and serum of broiler chickens fed with plant essential oils or virginiamycin.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 77 citations in OpenAlex.
- Enrofloxacin treatment alters cecal microbiota and metabolites and selects for fluoroquinolone-resistantMicrobiology spectrum · 2026Article
- Energy-sparing effect of oregano essential oil-lauric acid complex in broilers: Insights from serum metabolomics and 16S rRNA sequencing.Poultry science · 2026Article
- Dietary thyme essential oil supplementation improves production performance, egg quality, antioxidant status, and intestinal health in late-phase laying hens.Poultry science · 2026Article
- Threats and Opportunities When Using Chickens as a Model for Host-Microbiota Studies.Microorganisms · 2026Review
- Nutritional strategies to mitigate sub-clinical coccidiosis in Eimeria-challenged broilers.Poultry science · 2026Article
- The chicken gut microbiome in conventional and alternative production systems.Journal of animal science and biotechnology · 2025Review
- Impact of Drinking Water Supplemented with Complex Acidifiers on Production Performance, Egg Quality, Physiological and Biochemical Indicators, and Microbial Flora of BIAN Chickens.Life (Basel, Switzerland) · 2025Article
- Influence of Different Litter Regimens on Ceca Microbiota Profiles inAnimals : an open access journal from MDPI · 2025Article
- Elevated butyric acid and histamine in feces and serum as an indicator of onset of necrotic enteritis in broiler chickens.Frontiers in microbiology · 2025Article
- Effects of dietary supplementation with a thymol-carvacrol blend on growth performance and intestinal health of poultry.Frontiers in veterinary science · 2025Article
- Effects of antibiotics on chicken gut microbiota: community alterations and pathogen identification.Frontiers in microbiology · 2025Article
- Phytobiotics in poultry: revolutionizing broiler chicken nutrition with plant-derived gut health enhancers.Journal of animal science and biotechnology · 2024Review
- The effect of peanut skins as a natural antimicrobial feed additive on ileal and cecal microbiota in broiler chickens inoculated with Salmonella enterica Enteritidis.Poultry science · 2024Article
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- Essential oils as promising treatments for treatingFrontiers in pharmacology · 2024Review
- Essential oils mix effect on chicks ileal and caecal microbiota modulation: a metagenomics sequencing approach.Frontiers in veterinary science · 2024Article
- Lactiplantibacillus plantarum, lactiplantibacillus pentosus and inulin meal inclusion boost the metagenomic function of broiler chickens.Animal microbiome · 2023Article
- The Effect of Epimedium Isopentenyl Flavonoids on the Broiler Gut Health Using Microbiomic and Metabolomic Analyses.International journal of molecular sciences · 2023Article
- Dietary supplementation of solubles from shredded, steam-exploded pine particles modifies gut length and cecum microbiota in cyclic heat-stressed broilers.Poultry science · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the cecal microbiota and serum metabolite profile of chickens fed with plant essential oils (PEO) or virginiamycin (VIRG) using high-throughput 16S rRNA gene sequencing and untargeted metabolomics approach. The main aim of this work was to explore the biochemical mechanisms involved in the improved growth performance of antibiotics and their alternatives in animal production. The results showed that both PEO and VIRG treatment significantly increased the relative abundance of phyla Bacteroidetes and decreased the abundance of phyla Firmicutes and genus of Lactobacillus in cecal microbiota of chickens. Compared to the control group (CT group), the relative abundance of genus of Alistipes, unclassified Rikenellaceae, Roseburia, and Anaeroplasma was enriched in the PEO group; that of genus Bacteroides, Lachnospiraceae, and unclassified Enterobacteriaceae was enriched in the cecal microbiota of the VIRG group. Untargeted metabolomics analyses revealed that the PEO treatment modified 102 metabolites and 3 KEGG pathways (primary bile acid biosynthesis and phenylalanine metabolism) in the cecal microbiota, and 81 metabolites and relevant KEGG pathways (fructose and mannose metabolism, biosynthesis of unsaturated fatty acids, and linoleic acid.) in the serum of the chicken. Compared to the CT group, VIRG treatment group differed 217 metabolites and 10 KEGG pathways in cecal contents and 142 metabolites and 7 KEGG pathways in serum of chickens. Pearson's correlation analysis showed that phyla Bacteroidetes and genus of Bacteroides, Alistipes, and unclassified Rikenellaceae (in the VIRG and PE group) were positively correlated with many lipid metabolites. However, phyla Firmicutes and genera Lactobacillus (higher in the CT group) were negatively correlated with the lipid and thymine metabolism, and positively correlated with hydroxyisocaproic acid, cytosine, and taurine. This study shows that dietary supplementation with PEO and VIRG altered the composition and metabolism profile of the cecal microbiota, modified the serum metabolism profile.
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