Evidence map›Paper›PMID 32214024›Full record

ArticleHealthcare (Basel, Switzerland)2020

Morphogenetic Variability as Potential Biomarker of Neurogenic Lesion Degree in Children with Spina Bifida.

Ivana Petronic, Dragoslav Marinkovic, Dejan Nikolic, Dragana Cirovic, Zoran Golubovic, Filip Milanovic, Suzana Cvjeticanin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Healthcare (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ivana PetronicPhysical Medicine and Rehabilitation Department, University Children's Hospital, 11000 Belgrade, Serbia.
Dragoslav MarinkovicSerbian Academy of Sciences and Arts, Department of Chemical and Biological Sciences, 11000 Belgrade, Serbia.
Dejan NikolicPhysical Medicine and Rehabilitation Department, University Children's Hospital, 11000 Belgrade, Serbia.
Dragana CirovicPhysical Medicine and Rehabilitation Department, University Children's Hospital, 11000 Belgrade, Serbia.
Zoran GolubovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Filip MilanovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Suzana CvjeticaninFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
University of Belgrade · RSSerbian Academy of Sciences and Arts · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsIn this study we analyzed the degree of genetic homozygosity among spina bifida patients with different degrees of neurogenic lesion (

methodsAccording to clinical and electromyographic findings, we separately assessed the type of neurogenic lesion (paresis or paralysis). Regarding the degree of neurogenic lesion, patients were classified into three groups: mild, moderate and severe. We analyzed six muscles. For assessing the degree of individual genetic homozygosity, we tested the presence and distribution of 15 homozygous recessive characteristics (HRC).

resultsThe predominant type of neurogenic lesion was paresis. Every third evaluated muscle was affected in the group with mild neurogenic lesion, while more than half were affected in the group with severe neurogenic lesion. The average values of HRCs among different groups of patients and the control showed the population-genetic differences that exist among them (control

conclusionsSpina bifida patients have a significant increase of recessive homozygosity and a decreased variability compared to the control group. As neurogenic lesions are more severe, more affected muscles are present, as well as the increase of individual recessive homozygosity.

Indexed as

genetic homozygositygenetic variabilityneurogenic lesionspina bifida

Identifiers

PMID32214024
PMCPMC7151050
OpenAlexW3013800940

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.