Evidence map›Paper›PMID 32213936›Full record

ReviewInternational journal of molecular sciences2020

Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells.

Geoffrey Brown, Lucía Sánchez, Isidro Sánchez-García

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Cell Lineage Affiliation During Hematopoiesis.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Geoffrey BrownSchool of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Lucía SánchezSchool of Law, University of Salamanca, 37007 Salamanca, Spain.
Isidro Sánchez-GarcíaExperimental Therapeutics and Translational Oncology Program, Instituto de Biología Moleculary Celular del Cáncer, CSIC/Universidad de Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-6989-9905
Universidad de Salamanca · ESUniversity of Birmingham · GB

Funding

European Union's Seventh Framework Programme 315902Fundacion Unoentrecienmil CUNINA projectGerman Carreras Foundation DJCLS 02R-2016; DJCLS 07R/2019German Federal Office for Radiation Protection (BfS)-Germany FKZ: 3618S32274SAF2015-64420-R MINECO/FEDER,UE, RTI2018-093314-B-I00 MCIU/AEI/FEDER,UE, by Junta de Castilla y León UIC-017, CSI001U16, and CSI234P18
6 · The paper itself

Abstract

To produce the wide range of blood and immune cell types, haematopoietic stem cells can "choose" directly from the entire spectrum of blood cell fate-options. Affiliation to a single cell lineage can occur at the level of the haematopoietic stem cell and these cells are therefore a mixture of some pluripotent cells and many cells with lineage signatures. Even so, haematopoietic stem cells and their progeny that have chosen a particular fate can still "change their mind" and adopt a different developmental pathway. Many of the leukaemias arise in haematopoietic stem cells with the bulk of the often partially differentiated leukaemia cells belonging to just one cell type. We argue that the reason for this is that an oncogenic insult to the genome "hard wires" leukaemia stem cells, either through development or at some stage, to one cell lineage. Unlike normal haematopoietic stem cells, oncogene-transformed leukaemia stem cells and their progeny are unable to adopt an alternative pathway.

Indexed as

Cell LineageHematopoiesisAnimalsGene Expression Regulation, NeoplasticHematopoietic Stem CellsHumansLeukemiaNeoplastic Stem Cellscancerhaematopoiesisleukaemialineage decision makingoncogenesstem cells

Identifiers

PMID32213936
PMCPMC7139697
OpenAlexW3012964845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.