Evidence map›Paper›PMID 32213902›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-

Pasquale Linciano, Eleonora Gianquinto, Martina Montanari, Lorenzo Maso, Pierangelo Bellio, Esmeralda Cebrián-Sastre, Giuseppe Celenza, Jesús Blázquez, Laura Cendron, Francesca Spyrakis and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Approachable Synthetic Methodologies for Second-GenerationPharmaceuticals (Basel, Switzerland) · 2024
    Review
  3. Article
  4. Molecules (Basel, Switzerland) · 2022
    Article
  5. Review
  6. Article
  7. Multidrug ResistantFrontiers in microbiology · 2021
    Article
  8. Review
  9. 4-(Biomolecules · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Pasquale LincianoDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
Eleonora GianquintoDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.
Martina MontanariDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
Lorenzo MasoDepartment of Biology, University of Padua, Viale G. Colombo 3, 35121 Padua, Italy.ORCID 0000-0002-3380-2902
Pierangelo BellioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio 1, 67100 L'Aquila, Italy.ORCID 0000-0001-6488-8027
Esmeralda Cebrián-SastreNational Center of Biotechnology-CSIC, Calle Darwin 3, 28049 Madrid, Spain.
Giuseppe CelenzaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio 1, 67100 L'Aquila, Italy.
Jesús BlázquezNational Center of Biotechnology-CSIC, Calle Darwin 3, 28049 Madrid, Spain.
Laura CendronDepartment of Biology, University of Padua, Viale G. Colombo 3, 35121 Padua, Italy.
Francesca SpyrakisDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.ORCID 0000-0002-4016-227X
Donatella TondiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
University of Modena and Reggio Emilia · ITCentro Nacional de Biotecnología · ESUniversity of L'Aquila · ITUniversity of Padua · ITUniversity of Turin · IT

Funding

Università degli Studi di Modena e Reggio Emilia Fondo di Ateneo per la Ricerca di Ateneo FAR2014 FAR2017
6 · The paper itself

Abstract

The emergence of bacteria that co-express serine- and metallo- carbapenemases is a threat to the efficacy of the available

Indexed as

4-amino-1,2,4-triazole-3-thionebacterial resistancebroad-spectrum activitynon-covalent inhibitionstructure-based drug designthione/thiol tautomerism

Identifiers

PMID32213902
PMCPMC7151704
OpenAlexW3013411574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.