ArticleInternational journal of environmental research and public health2020
Analysis of Cumulative Cancer Risk Associated with Disinfection Byproducts in United States Drinking Water.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Disinfection Byproducts, Oxidative Stress, and Sleep Quality among Healthy Chinese Men.Environment & health (Washington, D.C.) · 2026Article
- Health risk assessment of disinfection by-products in drinking water on children and adolescents aged 6-17 in Ningbo city, China.Frontiers in public health · 2026Article
- Global research trends on the links between disinfection by-products and cancer: mapping knowledge landscapes and visualization analysis.Journal of water and health · 2025Review
- Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing.Analytical chemistry · 2025Article
- Disinfection byproducts in US drinking water and cancer mortality.International journal of environmental health research · 2025Article
- Quantitative Evaluation of Regulatory Indicators for Brominated Haloacetic Acids in Drinking Water.Environmental science & technology · 2025Article
- Review
- A Current Review of Water Pollutants in American Continent: Trends and Perspectives in Detection, Health Risks, and Treatment Technologies.International journal of environmental research and public health · 2023Review
- Estimating National Exposures and Potential Bladder Cancer Cases Associated with Chlorination DBPs in U.S. Drinking Water.Environmental health perspectives · 2022Article
- Community-Level Analysis of Drinking Water Data Highlights the Importance of Drinking Water Metrics for the State, Federal Environmental Health Justice Priorities in the United States.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hundreds of different disinfection byproducts form in drinking water following necessary treatment with chlorine and other disinfectants, and many of those byproducts can damage DNA and increase the risk of cancer. This study offers the first side-by-side comparison of cancer risk assessments based on toxicological and epidemiological studies of disinfection byproducts using a comprehensive contaminant occurrence dataset for haloacetic acids and trihalomethanes, two groups of disinfection byproducts that are regulated in drinking water. We also provide the first analysis of a new occurrence dataset for unregulated haloacetic acids that became available from the latest, fourth round of the U.S. EPA-mandated unregulated contaminant monitoring program (UCMR4). A toxicological assessment indicated that haloacetic acids, and in particular brominated haloacetic acids, are more carcinogenic and are associated with a greater number of attributable cancer cases than trihalomethanes. Based on the toxicological analysis, cumulative lifetime cancer risk due to exposure to trihalomethanes and haloacetic acids for community water systems monitored under UCMR4, estimated with standard default parameters for body weight and water intake, corresponds to 7.0 × 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.