Evidence map›Paper›PMID 32213731›Full record

ArticleThe Journal of veterinary medical science2020

Morphological evaluation of polysaccharide content and collagen composition during cutaneous wound healing in the Sunda porcupine (Hystrix javanica).

Andhika Yudha Prawira, Yoshinao Z Hosaka, Savitri Novelina, Wartika Rosa Farida, Huda Shalahudin Darusman, Srihadi Agungpriyono

Open access · diamondAbstract read
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Article in The Journal of veterinary medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Andhika Yudha PrawiraDepartment of Anatomy Physiology and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, Indonesia.
Yoshinao Z HosakaLaboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8550, Japan.
Savitri NovelinaDepartment of Anatomy Physiology and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, Indonesia.
Wartika Rosa FaridaZoology Division, Research Center for Biology, Indonesian Institute of Sciences, Cibinong 16911, Indonesia.
Huda Shalahudin DarusmanDepartment of Anatomy Physiology and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, Indonesia.
Srihadi AgungpriyonoDepartment of Anatomy Physiology and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, Indonesia.
IPB University · IDIndonesian Institute of Sciences · IDTottori University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing in the Sunda porcupine is believed to occur quickly, although the wound is large and severe. Wound enclosure involves many processes to restore the lost or damaged skin structure where conjugated polysaccharide-protein and collagen, as the main components deposited in wound tissue to restore it. The aim of this study was to evaluate alteration of polysaccharide contents and collagen in untreated full-thickness wound healing in the thoracodorsal and lumbosacral regions in the Sunda porcupines. Histological analysis was performed by periodic acid Schiff, alcian blue pH 2.5, picrosirius red staining method and Low Vacuum Scanning Electron Microscope (LV-SEM) imaging to obtain the fundamental data of healing process. Wound healing began with re-epithelization followed by progressive wound contraction with 4 overlapping stages in about 30-50 days until the wound closed (21-30 days in thoracodorsal and 30-50 days in lumbosacral). Neutral polysaccharide was more widely distributed compared to the acid polysaccharide in almost all stages of wound healing. The ratio of collagen I to III appeared to be higher in the thoracodorsal region than the lumbosacral region during healing process. LV-SEM imaging showed changes in connective tissue structure in the wound border and granulation tissue which appeared abundant and mixed of thin and thick fiber. In conclusion, cutaneous full thickness wound healing in the Sunda porcupine occurred faster in the thoracodorsal region, which might be correlated to the role of neutral polysaccharide and a high ratio of collagen I to III.

Indexed as

Wound HealingAnimalsCollagenPolysaccharidesPorcupinesSkinCollagenPolysaccharidescollagengranulation tissuematrix extracellularneutral polysaccharidere-epithelization

Identifiers

PMID32213731
PMCPMC7273595
OpenAlexW3013928470

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.