Evidence map›Paper›PMID 32213588›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans.

Diane Dayoung Park, Chatchai Phoomak, Gege Xu, Laura P Olney, Khiem A Tran, Simon S Park, Nathan E Haigh, Guillaume Luxardi, Worachart Lert-Itthiporn, Michiko Shimoda and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. Circulating microRNAs Expression as Prognosis Biomarker of Cholangiocarcinoma.Asian Pacific journal of cancer prevention : APJCP · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Metabolic control of glycosylation forms for establishing glycan-dependent protein interaction networks.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. ACS central science · 2024
    Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Diane Dayoung ParkDepartment of Chemistry, University of California, Davis, CA 95616; dpark4@bidmc.harvard.edu.ORCID 0000-0003-4983-4340
Chatchai PhoomakDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand.
Gege XuDepartment of Chemistry, University of California, Davis, CA 95616.ORCID 0000-0002-0792-2636
Laura P OlneyDepartment of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817.
Khiem A TranDepartment of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817.
Simon S ParkDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215.
Nathan E HaighDepartment of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817.
Guillaume LuxardiDepartment of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817.ORCID 0000-0003-3338-0583
Worachart Lert-ItthipornDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand.
Michiko ShimodaDepartment of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817.
Qiongyu LiDepartment of Chemistry, University of California, Davis, CA 95616.ORCID 0000-0003-3654-0378
Nobuyuki MatobaDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202.ORCID 0000-0001-7231-3004
Fernando FierroDepartment of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, CA 95817.ORCID 0000-0002-1086-2646
Sopit WongkhamDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand.
Emanual MaverakisDepartment of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA 95616.
University of California, Davis · USKhon Kaen University · THBeth Israel Deaconess Medical Center · USUniversity of Louisville · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
Investigation and Development of New Therapeutic Avenues for SclerodermaDP2OD008752 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MAVERAKIS, EMANUAL M. · 2011 to 2016
$2.8M
NCI NIH HHS P30 CA093373NIGMS NIH HHS R01 GM049077NIH HHS DP2 OD008752
6 · The paper itself

Abstract

Membrane-bound oligosaccharides form the interfacial boundary between the cell and its environment, mediating processes such as adhesion and signaling. These structures can undergo dynamic changes in composition and expression based on cell type, external stimuli, and genetic factors. Glycosylation, therefore, is a promising target of therapeutic interventions for presently incurable forms of advanced cancer. Here, we show that cholangiocarcinoma metastasis is characterized by down-regulation of the Golgi α-mannosidase I coding gene

Indexed as

AnimalsCell Line, TumorCell ProliferationCell Transformation, NeoplasticCholangiocarcinomaFemaleGlycosylationHumansMannoseMembrane GlycoproteinsMiceModels, MolecularNeoplasm MetastasisPhenotypeProtein MultimerizationMannoseMembrane Glycoproteinscholangiocarcinomaglycosylationmass spectrometrymembrane proteinsmetastasis

Identifiers

PMID32213588
PMCPMC7148571
OpenAlexW3013941621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.