Evidence map›Paper›PMID 32213534›Full record

ArticleESMO open2020

Current models, challenges and best practices for work conducted between European academic cooperative groups and industry.

Rolf A Stahel, Denis Lacombe, Fatima Cardoso, Paolo G Casali, Anastassia Negrouk, Richard Marais, Anita Hiltbrunner, Malvika Vyas, Clinical Academic Cancer Research Forum (CAREFOR)

Open access · goldAbstract read
In one paragraph

Article in ESMO open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Rolf A StahelMedical Oncology and Hematology, University Hospital Zürich, Zurich, Switzerland rolf.stahel@usz.ch.
Denis LacombeEORTC Headquarters, Brussels, Belgium.
Fatima CardosoBreast Unit, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.
Paolo G CasaliMedical Oncology Unit 2, National Cancer Institute: Fondazione IRCCS, Milano, Italy.
Anastassia NegroukEORTC Headquarters, Brussels, Belgium.
Richard MaraisMolecular Oncology, Cancer Research UK Manchester Institute, Greater Manchester, United Kingdom.
Anita HiltbrunnerEuropean Thoracic Oncology Platform, Bern, Switzerland.
Malvika VyasPublic Policy, European Society for Medical Oncology, Lugano, Switzerland.
Clinical Academic Cancer Research Forum (CAREFOR)
European Organisation for Research and Treatment of Cancer · BECancer Research UK Manchester Institute · GBChampalimaud Foundation · PTEuropean Society for Medical Oncology · CHFondazione IRCCS Istituto Nazionale dei Tumori · ITUniversity Hospital of Zurich · CH

Funding

Cancer Research UK 17240Cancer Research UK 19279Cancer Research UK 22902
6 · The paper itself

Abstract

backgroundThe academia-industry interface is important, and, despite challenges that inevitably occur, bears the potential for positive synergies to emerge. Perceived barriers to wider collaboration in academia-industry oncology research in Europe need to be addressed, current academic cooperative group and industry models for collaboration need to be discussed, and a common terminology to facilitate understanding of both sectors' concerns needs to be established with an eye towards improving academia-industry partnerships on clinical trials for the benefit of patients with cancer. METHODOLOGY: CAREFOR (Clinical Academic Cancer Research Forum), a multi-stakeholder platform formed to improve the direction for academic clinical trials in the field of oncology in Europe, formed the CAREFOR-Industry Working Group comprised of experienced professionals from European academic cooperative groups joined by industry representatives selected based on their activities in the area of medical oncology. They jointly discussed academic cooperative groups, clinical trials conducted between academic cooperative groups and industry, examples of successful collaborative models, common legal negotiation points in clinical trial contracts, data access, and principles of interaction.

resultsFour principles of interaction between the academia and industry are proposed: (1) clarify the roles and responsibilities of all partners involved in the study, (2) involve legal teams from an early stage; (3) acknowledge that data is an important output of the study, (4) agree on the intent of the trial prior to its start.

conclusionsThe CAREFOR-Industry Working Group describes current models, challenges, and effective strategies for academia-industry research in Europe with an eye towards improving academia-industry partnerships on clinical trials for patients with cancer. Current perceived challenges are explained, and future opportunities/recommendations for improvement are described for the areas of most significant impact. Challenges are addressed from both the academic and industry perspectives, and principles of interaction for the optimal alignment between academia and industry in selected areas are proposed.

Indexed as

Academies and InstitutesDrug IndustryEuropeHumansacademic groupsclinical trialsoncologypartnership modelspharmaceutical industry

Identifiers

PMID32213534
PMCPMC7103800
OpenAlexW3013112796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.