Evidence map›Paper›PMID 32213528›Full record

SynthesisHospital pediatrics2020

Vancomycin Dosing in Children With Overweight or Obesity: A Systematic Review and Meta-analysis.

Manaswitha Khare, Aniqa Azim, Garrett Kneese, Meredith Haag, Kelsey Weinstein, Kyung E Rhee, Byron Alexander Foster

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Hospital pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Manaswitha KhareDepartment of Pediatrics, University of California, San Diego, San Diego, California.
Aniqa AzimSchool of Medicine, Oregon Health and Science University, Portland, Oregon; and.
Garrett KneeseSchool of Medicine, Oregon Health and Science University, Portland, Oregon; and.
Meredith HaagSchool of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Kelsey WeinsteinSchool of Medicine, Oregon Health and Science University, Portland, Oregon; and.
Kyung E RheeDepartment of Pediatrics, University of California, San Diego, San Diego, California.
Byron Alexander FosterSchool of Medicine, Oregon Health and Science University, Portland, Oregon; and fosterb@ohsu.edu.
Oregon Health & Science University · USUniversity of California, San Diego · USThe University of Texas Health Science Center at San Antonio · US

Funding

Positive Deviance in Early Childhood ObesityK23DK109199 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOSTER, BYRON A · 2016 to 2019
$730k
NIDDK NIH HHS K23 DK109199
6 · The paper itself

Abstract

contextVancomycin is a medication with potential for significant harm with both overdosing and underdosing. Obesity may affect vancomycin pharmacokinetics and is increasingly common among children.

objectiveWe aimed to determine if children with overweight or obesity have increased vancomycin trough concentrations with total body weight (TBW) dosing compared with children with normal weight. DATA SOURCES: We conducted a search of Medline and Medline In-Process & Other Non-Indexed Citations from 1952 (the year vancomycin was discovered) to November 2017. STUDY SELECTION: Search terms included vancomycin, body weight, and body composition terms and were limited to children. Studies were reviewed and screened by ≥2 reviewers. DATA EXTRACTION: The primary outcome was vancomycin level. Data were extracted by 2 reviewers. We performed quality assessment using the Newcastle-Ottawa quality assessment scale.

resultsWe identified 271 records. After abstract and full-text screening, we identified 7 studies for full review. Six of the 7 studies used a matched case-control design, although there was significant variation in study methodology. Four of the 7 studies were included in a meta-analysis, which revealed a small but significant difference in vancomycin trough levels between children with normal weight and children with overweight or obesity when dosed by using TBW (

conclusionsHigh-quality data to guide vancomycin dosing in children with obesity are lacking. More studies evaluating dosing strategies in children with obesity are warranted because using TBW to dose vancomycin may lead to higher vancomycin concentrations and potential toxicity.

Indexed as

Anti-Bacterial AgentsOverweightPediatric ObesityVancomycinChildHumansAnti-Bacterial AgentsVancomycin

Identifiers

PMID32213528
PMCPMC7106776
OpenAlexW3013010105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.