ArticleeLife2020
Endogenous siRNAs promote proteostasis and longevity in germline-less
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Mutual regulation of spermatogenesis-specific Argonaute proteins and Insulin/IGF-1 signaling in aging control.EMBO reports · 2026Article
- Nematode mind: exploring the role of the RNA interference pathway in learning, memory and beyond.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Using RNA therapeutics to promote healthy aging.Nature aging · 2025Review
- Sex-specific growth and lifespan effects of germline removal in the dioecious nematode Caenorhabditis remanei.Aging cell · 2024Article
- Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans.Nature communications · 2024Article
- Decoding lifespan secrets: the role of the gonad inFrontiers in aging · 2024Review
- piRNAs regulate a Hedgehog germline-to-soma pro-aging signal.Nature aging · 2023Article
- Repetitive DNA is Functional and Encodes Parts of the Non-Coding RNA Repertoire.Advanced genetics (Hoboken, N.J.) · 2022Article
- Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Antiaging agents: safe interventions to slow aging and healthy life span extension.Natural products and bioprospecting · 2022Review
- Gonadotropin-releasing hormone-like receptor 2 inversely regulates somatic proteostasis and reproduction inFrontiers in cell and developmental biology · 2022Article
- Neuronal regulatedeLife · 2021Article
- Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice.GeroScience · 2021Article
- Inhibition of mTOR decreases insoluble proteins burden by reducing translation in C. elegans.Biogerontology · 2021Article
- Recent advances in understanding the role of proteostasis.Faculty reviews · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep sequencing and genomic and genetic approaches in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.