Evidence map›Paper›PMID 32213287›Full record

ArticleeLife2020

Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function.

Eduardo Javier López Soto, Diane Lipscombe

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

  1. Channels (Austin, Tex.) · 2026
    Article
  2. Nociceptor-enriched CAPS1 isoform couples to CabioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Neuroepigenetic Editing.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  9. No significant change of NBrain and behavior · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eduardo Javier López SotoThe Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, Providence, United States.ORCID 0000-0003-3298-8001
Diane LipscombeThe Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, Providence, United States.ORCID 0000-0002-7146-9119
Allen Institute for Brain Science · US

Funding

Voltage-Gated Calcium Channels in Nociceptors and MechanoreceptorsR01NS055251 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE · 2006 to 2025
$9.1M
Abnormal gene splicing in neuropathic pain - SupplementK99NS116123 · NINDS · BROWN UNIVERSITY · PI LOPEZ SOTO, EDUARDO JAVIER · 2020 to 2021
$184k
NINDS NIH HHS K99 NS116123NINDS NIH HHS NS055251NINDS NIH HHS R01 NS055251
6 · The paper itself

Abstract

Cell-specific alternative splicing modulates myriad cell functions and is disrupted in disease. The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors. In sensory neurons, cell-specific alternative splicing of the presynaptic Ca

Indexed as

Alternative SplicingDNA MethylationExonsAnimalsCalcium Channels, N-TypeCCCTC-Binding FactorCell LineageCells, CulturedDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AGanglia, SpinalMiceNeuronsPeripheral Nerve InjuriesTRPV Cation ChannelsCacna1b protein, mouseCalcium Channels, N-TypeCCCTC-Binding FactorCtcf protein, mouseDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ATRPV1 protein, mouseTRPV Cation Channelsalternative splicingcell biologychronic painepigenetic regulationion channelmorphinemouseneurosciencenociceptor

Identifiers

PMID32213287
PMCPMC7124252
OpenAlexW3013261524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.