Evidence map›Paper›PMID 32213122›Full record

ArticleMolecular biology of the cell2020

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.

Kaylee Steen, Desu Chen, Fengrong Wang, Ritankar Majumdar, Song Chen, Surinder Kumar, David B Lombard, Roberto Weigert, Abigail G Zieman, Carole A Parent and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

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  8. The desmosome comes into focus.The Journal of cell biology · 2024
    Review
  9. Colonocyte keratins stabilize mitochondria and contribute to mitochondrial energy metabolism.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  10. Article
  11. Review
  12. Article
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  14. Article
  15. Article
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  19. Article
  20. In-cell structures of conserved supramolecular protein arrays at the mitochondria-cytoskeleton interface in mammalian sperm.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kaylee SteenDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
Desu ChenLaboratory for Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Fengrong WangDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
Ritankar MajumdarDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109.
Song ChenDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109.
Surinder KumarDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109.
David B LombardDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109.
Roberto WeigertLaboratory for Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Abigail G ZiemanDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
Carole A ParentDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
Pierre A CoulombeDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
University of Michigan–Ann Arbor · USCenter for Cancer Research · USNational Cancer Institute · USU-M Rogel Cancer Center

Funding

Molecular mechanisms of membrane remodelingZIABC011682 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WEIGERT, ROBERTO · 2016 to 2025
$17.5M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Non-Canonical Functions of Keratin Proteins in SkinR01AR044232 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COULOMBE, PIERRE · 1996 to 2020
$8.6M
TYPE II KERATIN GENES /PROTEINS IN COMPLEX EPITHELIAR01AR042047 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COULOMBE, PIERRE · 1995 to 2018
$7.1M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
TRAINING PROGRAM IN CELL AND MOLECULAR DERMATOLOGYT32AR007197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES TILFORD ELDER, Sunny Y Wong · 1986 to 2026
$4.2M
Regulation of one carbon metabolism and epigenetics by SIRT5R01GM101171 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOMBARD, DAVID BENNER · 2012 to 2021
$2.6M
Role of keratin intermediate filaments in skin epithelial architecture and homeostasisR56AR042047 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COULOMBE, PIERRE · 2020 to 2020
$429k
NCI NIH HHS T32 CA009110NIAMS NIH HHS 5T32AR007197-40NIAMS NIH HHS R01 AR042047NIAMS NIH HHS R01 AR044232NIAMS NIH HHS R56 AR042047NIAMS NIH HHS T32 AR007197NIA NIH HHS T32 AG029796NIGMS NIH HHS R01 GM101171
6 · The paper itself

Abstract

Mitochondria fulfill essential roles in ATP production, metabolic regulation, calcium signaling, generation of reactive oxygen species (ROS), and additional determinants of cellular health. Recent studies have highlighted a role for mitochondria during cell differentiation, including in skin epidermis. The observation of oxidative stress in keratinocytes from

Indexed as

AnimalsCytoskeletal ProteinsEpidermisFemaleKeratin-16Keratin-6KeratinocytesKeratinsKeratoderma, PalmoplantarMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMutationPachyonychia CongenitaCytoskeletal ProteinsKeratin-16Keratin-6KeratinsKrt16 protein, mouseKrt6a protein, mouse

Identifiers

PMID32213122
PMCPMC7353162
OpenAlexW3013984393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.