Observational studyUnited European gastroenterology journal2020
Gastric cancer in autoimmune gastritis: A case-control study from the German centers of the staR project on gastric cancer research.
Observational study in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Risk of Gastric Neoplasms in Patients with Autoimmune Gastritis: A Systematic Review and Meta-Analysis.Gut and liver · 2026Pooled it
- Mismatch repair deficiency, chemotherapy and survival for resectable gastric cancer: an observational study from the German staR cohort and a meta-analysis.Journal of cancer research and clinical oncology · 2023Pooled it
- ISPAD, bridging clinical expertise and AI for autoimmune-related pernicious anemia diagnosis.Frontiers in immunology · 2026Article
- Gastric cancer in patients withWorld journal of gastrointestinal oncology · 2025Article
- Autoimmune Gastritis in Korean Patients with Gastric Tumors: Clinicopathologic Correlations and Diagnostic Histological Features.Gut and liver · 2025Article
- Real-Time Gastric Juice Analysis to Rule Out the Presence of Autoimmune Gastritis: A Case-Control Study.GE Portuguese journal of gastroenterology · 2025Article
- Characteristics of Early Gastric Cancer in a Patient with a History of Helicobacter pylori Infection and No History of Eradication Therapy.Internal medicine (Tokyo, Japan) · 2025Article
- Association between autoimmune gastritis and gastric polyps: Clinical characteristics and risk factors.World journal of gastrointestinal oncology · 2025Article
- Age-Related Differences in Clinical Presentation of Autoimmune Gastritis: A Retrospective Comparative Study.Gastroenterology research and practice · 2025Article
- Autoimmune gastritis studies and gastric cancer: True renaissance or bibliometric illusion.World journal of gastroenterology · 2024Review
- Gastric Adenocarcinoma in Helicobacter pylori-Negative Autoimmune Gastritis: A Case Report and Literature Review.Cureus · 2024Article
- Article
- Clinicopathological Features of Early Gastric Cancer Complicated by Autoimmune Gastritis.Digestive diseases (Basel, Switzerland) · 2024Article
- A Case of Gastric Adenocarcinoma With Pernicious Anemia, Polyneuropathy, and Subacute Combined Degeneration Caused by Autoimmune Gastritis.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Clinicopathological characteristics of gastric cancer patients with dermatomyositis and analysis of perioperative management: a case series study.Frontiers in surgery · 2023Article
- The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis.Diagnostics (Basel, Switzerland) · 2022Article
- Clinicopathological Features of Gastric Cancer with Autoimmune Gastritis.Biomedicines · 2022Article
- Mixed neuroendocrine-non-neuroendocrine neoplasm associated with autoimmune gastritis.Clinical case reports · 2022Article
- Clinicopathological characteristics of early gastric cancer associated with autoimmune gastritis.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Review
Corrections and comments
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Authors and funding
25 authors at 16 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPatients with autoimmune gastritis (AIG) are reported to have an increased risk of developing gastric cancer (GC). In this study, we assess the characteristics and outcomes of GC patients with AIG in a multicenter case-control study.
methodsBetween April 2013 and May 2017, patients with GC, including cancers of the esophagogastric junction (EGJ) Siewert type II and III, were recruited. Patients with histological characteristics of AIG were identified and matched in a 1:2 fashion for age and gender to GC patients with no AIG. Presenting symptoms were documented using a self-administered questionnaire.
resultsHistological assessment of gastric mucosa was available for 572/759 GC patients. Overall, 28 (4.9%) of GC patients had AIG (67 ± 9 years, female-to-male ratio 1.3:1). In patients with AIG, GC was more likely to be localized in the proximal (i.e. EGJ, fundus, corpus) stomach (odds ratio (OR) 2.7, 95% confidence interval (CI) 1.0-7.1). In GC patients with AIG, pernicious anemia was the leading clinical sign (OR 22.0, 95% CI 2.6-187.2), and the most common indication for esophagogastroduodenoscopy (OR 29.0, 95% CI 7.2-116.4). GC patients with AIG were more likely to present without distant metastases (OR 6.2, 95% CI 1.3-28.8) and to be treated with curative intention (OR 3.0, 95% CI 1.0-9.0). The five-year survival rates with 95% CI in GC patients with and with no AIG were 84.7% (83.8-85.6) and 53.5% (50.9-56.1), respectively (OR 0.25, 95% CI 0.08-0.75,
conclusionsPernicious anemia leads to earlier diagnosis of GC in AIG patients and contributes significantly to a better clinical outcome.
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