SynthesisUnited European gastroenterology journal2020
Predicting lymph node metastases with endoscopic resection in cT2N0M0 oesophageal cancer: A systematic review and meta-analysis.
Synthesis in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Predictors of Understaging with EUS and PET-CECT in Early Esophageal Carcinoma.Journal of gastrointestinal cancer · 2024Article
- Dual-energy computed tomography for predicting cervical lymph node metastasis in laryngeal squamous cell carcinoma.Heliyon · 2024Article
- A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Mitochondrial calcium uniporter promotes cell proliferation and migration in esophageal cancer.Oncology letters · 2021Article
- Clinical TNM staging for esophageal, gastric, and colorectal cancers in the era of neoadjuvant therapy: A systematic review of the literature.Annals of gastroenterological surgery · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite modern imaging modalities, staging of clinically staged T2N0M0 (cT2N0M0) oesophageal cancer is suboptimal, often leading to overtreatment. Endoscopic resection - the first-line therapy for early localised tumours - could be used to improve staging and to attain predictors of nodal upstaging enabling more stage-guided treatment decisions.
objectiveA systematic literature review and a meta-analysis were conducted to assess the prevalence and the pathological risk factors of lymph node metastases in cT2N0M0 oesophageal cancer.
methodsDatabases of PUBMED, EMBASE and Cochrane were searched for literature. The primary outcome was lymph node metastases determined after primary surgical resection.
resultsNine studies with a total of 1650 cT2N0M0 patients were included. The prevalence of lymph node metastases was 43% (95% confidence interval: 35-50%) with heterogeneity being high across studies (
conclusionsClinical lymph node staging is inaccurate in almost half of cT2N0M0 oesophageal cancer. Endoscopic resection is a promising diagnostic modality that might even be a valid alternative to surgery in selected patients without high-risk features, but further evidence is warranted.
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