Evidence map›Paper›PMID 32213042›Full record

ArticleUnited European gastroenterology journal2020

Antimicrobial therapy of 3 days or less is sufficient after successful ERCP for acute cholangitis.

Sylke Haal, Britt Ten Böhmer, Sebastiaan Balkema, Annekatrien Ctm Depla, Paul Fockens, Jeroen M Jansen, Sjoerd D Kuiken, Boris I Liberov, Ellert van Soest, Jeanin E van Hooft and 2 more

Abstract readMulticenter Study
In one paragraph

Article in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. ShortWorld journal of gastroenterology · 2023
    Pooled it
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  11. Antimicrobial therapy outcomes in acute cholangitis: Hilar multiple obstructionsJGH open : an open access journal of gastroenterology and hepatology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sylke HaalDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, Netherlands.
Britt Ten BöhmerDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, Netherlands.
Sebastiaan BalkemaDepartment of Gastroenterology, Dijklander Ziekenhuis, Hoorn, Netherlands.
Annekatrien Ctm DeplaDepartment of Gastroenterology, MC Slotervaart, Amsterdam, Netherlands.
Paul FockensDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, Netherlands.
Jeroen M JansenDepartment of Gastroenterology and Hepatology, OLVG, Amsterdam, Netherlands.
Sjoerd D KuikenDepartment of Gastroenterology and Hepatology, OLVG, Amsterdam, Netherlands.
Boris I LiberovDepartment of Internal medicine, Zaans Medisch Centrum, Zaandam, Netherlands.
Ellert van SoestDepartment of Gastroenterology, Spaarne Gasthuis, Hoofddorp, Netherlands.
Jeanin E van HooftDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, Netherlands.
Elske SieswerdaDepartment of Medical Microbiology and Infection Control, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Rogier P VoermansDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecommendations for the duration of antimicrobial therapy in cholangitis after successful endoscopic biliary drainage vary. The aim of this study was to compare the occurrence of local infectious complications in patients with acute cholangitis treated with antibiotics for 3 days or less compared with 4 days or more.

methodsWe performed a retrospective multicentre study in seven hospitals in the Netherlands. Patients who received a successful biliary drainage by endoscopic retrograde cholangio-pancreatography because of cholangitis due to common bile duct stones between 2012 and 2017 were included. The primary outcome was the occurrence of a local infectious complication within 3 months of endoscopic retrograde cholangio-pancreatography. Secondary outcomes included

resultsA total of 426 patients with cholangitis were identified and 296 patients met all inclusion criteria. Therapy duration was ≤3 days in 137 patients (46.3%). During follow-up, 41 patients (13.9%) developed a local infectious complication. Occurrence of infectious complications did not differ between the two groups (

conclusionsAntimicrobial therapy of 3 days or less seems to be sufficient after successful biliary drainage in patients with acute cholangitis. Randomized trials should confirm our findings.

Indexed as

Acute DiseaseAgedAged, 80 and overAnti-Bacterial AgentsAntibiotic ProphylaxisCholangiopancreatography, Endoscopic RetrogradeCholangitisCholedocholithiasisClostridioides difficileClostridium InfectionsCommon Bile DuctDrainageFemaleFollow-Up StudiesHospital MortalityHumansAnti-Bacterial AgentsAcute cholangitisantimicrobial stewardshiptreatment duration

Identifiers

PMID32213042
PMCPMC7226689

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.