Evidence map›Paper›PMID 32213037›Full record

Trial reportUnited European gastroenterology journal2020

A novel PillCam Crohn's capsule score (Eliakim score) for quantification of mucosal inflammation in Crohn's disease.

Rami Eliakim, Doron Yablecovitch, Adi Lahat, Bella Ungar, Eyal Shachar, Dan Carter, Limor Selinger, Sandra Neuman, Shomron Ben-Horin, Uri Kopylov

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Observational
  7. Article
  8. [Value of different endoscopic scoring methods in assessing disease activity in pediatric Crohn's disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Is Panenteric PillcamDiagnostics (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rami EliakimDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Doron YablecovitchDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Adi LahatDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Bella UngarDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Eyal ShacharDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Dan CarterDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Limor SelingerDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Sandra NeumanDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Shomron Ben-HorinDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
Uri KopylovDepartment of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCapsule endoscopy is an important modality for monitoring of Crohn's disease. Recently, a novel panenteric capsule, PillCam Crohn's (Medtronic, USA), was approved for use. No quantitative index of inflammation for this method is currently available. This sub-study of a prospective randomized controlled Comprehensive individUalized pRoactive ThErapy of Crohn's Disease trial (CURE-CD) which aimed to compare the correlation and reliability of the novel PillCam Crohn's score with the existing small bowel capsule Lewis inflammatory score.

methodsThe study cohort included Crohn's disease patients in remission who were evaluated with PillCam Crohn's. Each result was independently reviewed by two experienced readers. Inflammation was scored in all studies using Lewis inflammatory score and PillCam Crohn's score (comprised of a sum of scores for most common and most severe lesions multiplied by percentage of segmental involvement + stricture score).

resultsFifty-four PillCam Crohn's studies from 41 patients were included. The median Lewis inflammatory score was 225 for both readers. The median PillCam Crohn's score was six (0-14) and four (3-15) for readers 1 and 2, respectively. There was a high inter-rater reliability coefficient between the two readers for Lewis inflammatory and PillCam Crohn's score (0.9,

conclusionsThe novel panenteric capsule score correlates well with the Lewis inflammatory score, has excellent reliability, and may be potentially more accurate in estimation of the panenteric inflammatory burden.

Indexed as

Severity of Illness IndexAdultCapsule EndoscopyCrohn DiseaseFemaleHumansIntestinal MucosaIntestine, SmallMaleProspective StudiesReproducibility of ResultsYoung Adultcapsule endoscopyCrohn’s diseasemonitoring Crohn’s diseasePillCam Crohn’streat to target

Identifiers

PMID32213037
PMCPMC7268948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.