Evidence map›Paper›PMID 32213023›Full record

ArticleUnited European gastroenterology journal2020

Novel reliability criteria for controlled attenuation parameter assessments for non-invasive evaluation of hepatic steatosis.

Georg Semmler, Katharina Wöran, Bernhard Scheiner, Lukas Walter Unger, Rafael Paternostro, Judith Stift, Philipp Schwabl, Theresa Bucsics, David Bauer, Benedikt Simbrunner and 5 more

Abstract readEvaluation Study
In one paragraph

Article in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Non-Invasive Stratification of Portal Hypertension in Patients With BCR::ABL1-Negative Myeloproliferative Neoplasms.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  6. Article
  7. Elevated Hepatic Copper Content in Porto-Sinusoidal Vascular Disorder (PSVD): Leading Down a Wrong Track.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Vibration-controlled Transient Elastography in NAFLD: Review Study.Euroasian journal of hepato-gastroenterology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Georg SemmlerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-0411-166X
Katharina WöranClinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Bernhard ScheinerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Lukas Walter UngerDivision of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-8423-2268
Rafael PaternostroDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1813-5769
Judith StiftClinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Philipp SchwablDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Theresa BucsicsDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
David BauerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Benedikt SimbrunnerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-8181-9146
Albert Friedrich StättermayerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Matthias PinterDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Michael TraunerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Thomas ReibergerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-4590-3583
Mattias MandorferDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2330-0017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is conflicting evidence regarding reliability criteria for the controlled attenuation parameter (CAP; a marker for hepatic steatosis [HS]). Thus, we assessed the diagnostic performance of CAP according to different reliability criteria based on real-world data from an academic centre.

methodsPatients undergoing measurement of CAP and liver biopsy (±6 months) at the Medical University of Vienna were included. HS was assessed according to SAF score.

resultsIn total 319 patients were included. The main aetiologies were non-alcoholic fatty liver disease (NAFLD,

conclusionCAP-IQR/median<0.1, <0.2, and <0.3 identify reliable measurements for diagnosing any hepatic steatosis (≥S1). Importantly, CAP-IQR/median<0.3 has a considerably higher applicability in clinical practice, as compared with the previously suggested CAP-IQR<40 dB/m criterion.

Indexed as

AdultBiopsyElasticity Imaging TechniquesFatty Liver, AlcoholicFemaleHepatitis, Viral, HumanHumansLiverLiver CirrhosisMaleMiddle AgedNon-alcoholic Fatty Liver DiseasePredictive Value of TestsReproducibility of ResultsRetrospective StudiesROC CurveCAPControlled attenuation parameterFibroScanhepatic steatosisIQRNAFLDnon-alcoholic fatty liver diseasereliabilityVCTEvibration-controlled transient elastography

Identifiers

PMID32213023
PMCPMC7184665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.