Evidence map›Paper›PMID 32212858›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

Comparison of high-fat style diet-induced dysregulation of baroreflex control of renal sympathetic nerve activity in intact and ovariectomized female rats: Renal sympathetic nerve activity in high-fat style diet fed intact and ovariectomized female rats.

Yamuna Sucedaram, Edward James Johns, Ruby Husain, Munavvar Abdul Sattar, Mohammed Abdulla, Manizheh Khalilpourfarshbafi, Nor Azizan Abdullah

Abstract readComparative Study
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yamuna SucedaramDepartment of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Edward James JohnsDepartment of Physiology, University College Cork, Cork T12 K8AF, Ireland.
Ruby HusainDepartment of Physiology, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Munavvar Abdul SattarSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, USM Pulau Pinang 11800, Malaysia.
Mohammed AbdullaDepartment of Physiology, University College Cork, Cork T12 K8AF, Ireland.
Manizheh KhalilpourfarshbafiDepartment of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Nor Azizan AbdullahDepartment of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0003-0963-2373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementOver activation of renal sensory nerve in obesity blunts the normal regulation of renal sympathetic nerve activity. To date, there is no investigation that has been carried out on baroreflex regulation of renal sympathetic nerve activity in obese ovarian hormones deprived rat model, and the effect of renal denervation on the baroreflex regulation of renal sympathetic nerve activity. Thus, we investigated the role of renal innervation on baroreflex regulation of renal sympathetic nerve activity in obese intact and ovariectomized female rats. Our data demonstrated that in obese states, the impaired baroreflex control is indistinguishable between ovarian hormones deprived and non-deprived states. This study will be of substantial interest to researchers working on the impact of diet-induced hypertension in pre- and postmenopausal women. This study provides insight into health risks amongst obese women regardless of their ovarian hormonal status and may be integrated in preventive health strategies.

Indexed as

AnimalsBaroreflexBlood PressureDiet, High-FatFemaleKidneyOvariectomyRatsRats, Sprague-DawleySympathetic Nervous SystemBaroreflexhigh-fat dietobesityovariectomyrenal denervationrenal sympathetic nerve activity

Identifiers

PMID32212858
PMCPMC7273891

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.