Evidence map›Paper›PMID 32212808›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Opium Use and Head and Neck Cancers: A Matched Case-Control Study in Iran.

Hosniyeh Alizadeh, Ahmad Naghibzadeh Tahami, Narges Khanjani, Vahid Yazdi-Feyzabadi, Hadi Eslami, Vahidreza Borhaninejad, Mohammad Hasan Larizadeh, Ahmad Enhesari, Reza Abbasi-Rayeni, Vahid Moazed and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  11. Observational
  12. Overexpression of Adiponectin Receptors in Opium Users with and without Cancer.Clinical pharmacology : advances and applications · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Hosniyeh AlizadehNeuroscience Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Ahmad Naghibzadeh TahamiPhysiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Narges KhanjaniEnvironmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Vahid Yazdi-FeyzabadiHealth Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Hadi EslamiDepartment of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Vahidreza BorhaninejadSocial Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad Hasan LarizadehDepartment of Radiation Oncology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Ahmad EnhesariClinical Research Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Reza Abbasi-RayeniEndocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Vahid MoazedDepartment of Hematology and Oncology, Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran.ORCID 0000-0003-0525-4539
Aliasghar Arabi MianroodiDepartment of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Kerman University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead and Neck (H and N) cancers include malignant tumors of the nasal cavity, pharynx, paranasal sinuses, oral cavity, larynx and salivary glands. Opium use might be related to these cancers. The aim of this study was to investigate the relation between Opium and its Derivatives (O and D) use and the incidence of H and N cancers.

methodsIn this case-control study conducted in Kerman, 140 patients with HandN cancers and 280 healthy controls (matched for age, gender, and place of residence) were included. Information about their use of O and D, cigarette smoking, alcohol and diet were collected using a structured questionnaire. Conditional logistic regression was used to investigate the relation between variables.

resultsThe use of opioids was associated with an increased risk of H and N cancers (Adjusted OR: 8.13; CI: 4.08-16.2). A significant dose-response relation between O and D use was observed, with high use Adjusted OR=8.91; 95% CI: 4.03-19.65 and low use Adjusted OR=6.52; 95% CI: 3.18- 13.36. This dose-response association was stronger in patients with laryngeal cancer and opioids use, with high use Adjusted OR = 11.17; 95% CI=4.48-28.09 and low use Adjusted OR = 9.46; 95% CI= 3.97- 22.52.

conclusionThe results show that opium use can be considered as an important risk factor for H and N cancers. Also in Iran, opium seems to play a more important role than cigarette smoking.

Indexed as

AgedAlcohol DrinkingCase-Control StudiesFemaleHead and Neck NeoplasmsHumansIranMaleMiddle AgedOpiumSmokingOpiumCase-controlhead & neck neoplasmsIranOpiumrisk factor

Identifiers

PMID32212808
PMCPMC7437338
OpenAlexW3013615829

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.