Evidence map›Paper›PMID 32212791›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Arg399Gln XRCC1 Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck in Jordanian Patients.

Ammar Sobiahe, Eman Hijazi, Hamzeh J Al-Ameer, Yazan Almasri, Yazun Jarrar, Malek Zihlif, Maha Shomaf, Baeth Al-Rawashdeh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ammar SobiaheDepartment of Dental Surgery, Islamic Hospital, Amman, Jordan.
Eman HijaziDepartment of Pathology, Islamic Hospital, Amman, Jordan.
Hamzeh J Al-AmeerDepartment of Biology and Biotechnology, American University of Madaba, Madaba, Jordan.
Yazan AlmasriDepartment of Pharmacology, Faculty of Medicine, The University of Jordan, Amman, Jordan.
Yazun JarrarDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Malek ZihlifDepartment of Pharmacology, Faculty of Medicine, The University of Jordan, Amman, Jordan.
Maha ShomafDepartment of Pathology, The University of Jordan, Amman, Jordan.
Baeth Al-RawashdehDepartment of Otolaryngology and Head and Neck Surgery, The University of Jordan, Amman, Jordan.
University of Jordan · JOAl-Zaytoonah University of Jordan · JOAmerican University of Madaba · JOIslamic Hospital · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveX-ray repair cross-complementing group1 (XRCC1) is a key protein in base excision repair and closely associated with the coordination of the base excision repair pathway. Many studies have focused on XRCC1 SNPs and have shown an associated between these SNPs and the risk of several types of cancers, including head and neck cancer. There are many single nucleotide polymorphisms XRCC1 gene (SNPs) and the most common SNP that result in amino acid substitutions is exon 10 (Arg399Gln). This study aimed to investigate the association between Arg399Gln SNP and the risk of squamous cell carcinoma of the head and neck. MATERIAL AND

methodNinety nine patients with squamous cell carcinomas of the head and neck and 89 healthy adult controls were enrolled in this study. The Arg399Gln in XRCC1 allele was genotyped using polymerase chain reaction-restriction fragment length polymorphism method.

resultsIn the single-locus analyses, Arg399Gln SNP showed a significant association with head and neck cancer risk (p value = 0.016 and odd ratio of 1.8). On the genotype level, we applied three analysis models, namely co-dominant, dominant, and recessive genotypes. Arg/Arg homozygous major genotype was significantly (p value <0.05) associated with head and neck squamous cell carcinoma incidence with odd ratio of 2.23 and 2.24 for the co-dominant and recessive models, respectively.

conclusionThe findings indicated that Arg399Gln allele was associated with squamous cell carcinoma of the head and neck among Jordanian patients. This allele might be used as a genetic biomarker of squamous cell carcinoma of the head and neck.

Indexed as

Polymorphism, Single NucleotideAdultAgedArginineFemaleGlutamineHead and Neck NeoplasmsHumansMaleMiddle AgedSquamous Cell Carcinoma of Head and NeckX-ray Repair Cross Complementing Protein 1ArginineGlutamineX-ray Repair Cross Complementing Protein 1XRCC1 protein, humanGenotypehead and neckSquamous Cell CarcinomaXRCC1

Identifiers

PMID32212791
PMCPMC7437344
OpenAlexW3013794053

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.