Evidence map›Paper›PMID 32212362›Full record

ArticleHaemophilia : the official journal of the World Federation of Hemophilia2020

Proteoglycan synthesis rate as a novel method to measure blood-induced cartilage degeneration in non-haemophilic and haemophilic rats.

Astrid E Pulles, Kåre K Vøls, Kristine R Christensen, Katja Coeleveld, Axel K Hansen, Lize F D van Vulpen, Maj Petersen, Simon C Mastbergen, Kirstine Roepstorff, Roger E G Schutgens and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haemophilia : the official journal of the World Federation of Hemophilia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Haemophilia.Nature reviews. Disease primers · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Astrid E PullesDepartment of Rheumatology & Clinical Immunology, University Medical Center (UMC) Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-8464-4775
Kåre K VølsGlobal Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.ORCID https://orcid.org/0000-0002-6701-2087
Kristine R ChristensenVeterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Katja CoeleveldDepartment of Rheumatology & Clinical Immunology, University Medical Center (UMC) Utrecht, Utrecht University, Utrecht, The Netherlands.
Axel K HansenVeterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Lize F D van VulpenVan Creveldkliniek, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0003-3242-5524
Maj PetersenGlobal Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
Simon C MastbergenDepartment of Rheumatology & Clinical Immunology, University Medical Center (UMC) Utrecht, Utrecht University, Utrecht, The Netherlands.
Kirstine RoepstorffLEO Pharma A/S, Ballerup, Denmark.
Roger E G SchutgensVan Creveldkliniek, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-2762-6033
Mads Kjelgaard-HansenVeterinary Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Floris P J G LafeberDepartment of Rheumatology & Clinical Immunology, University Medical Center (UMC) Utrecht, Utrecht University, Utrecht, The Netherlands.
University of Copenhagen · DKUniversity of Applied Sciences Utrecht · NLUtrecht University · NLLeo Pharma (Denmark) · DKNovo Nordisk (Denmark) · DK

Funding

Novo Nordisk A/S
6 · The paper itself

Abstract

introductionHaemophilic animal models are used to study blood-induced cartilage damage, but quantitative and sensitive outcome measures are needed.

aimTo develop a novel quantitative method for detecting early cartilage degeneration in a haemophilic rat model of blood-induced joint damage.

methodsThe

resultsIn vitro, a decrease in PSR in tibial and patellar cartilage was demonstrated following blood exposure. In vivo, joint diameter and development of bone pathology confirmed successful induction of haemarthrosis. In the blood-exposed knee, tibial and patellar PSR was inhibited 4 and 16 days after induced haemarthrosis. Interestingly, at day 16 the proteoglycan synthesis in the contralateral knee was also inhibited to an extent correlating with that of the blood-exposed knee.

conclusionFor the first time, early changes in cartilage matrix synthesis upon blood exposure were quantified with the

Indexed as

AnimalsCartilage, ArticularDisease Models, AnimalHemophilia AHumansMaleProteoglycansRatsProteoglycansarthropathiescartilageexperimental animal modelshaemarthrosishaemophilia

Identifiers

PMID32212362
PMCPMC7318356
OpenAlexW3013319986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.