ArticleMicrobial biotechnology2020
Metabolic modulation of redox state confounds fish survival against Vibrio alginolyticus infection.
Article in Microbial biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of Natural Ingredient Xanthohumol on the Intestinal Microbiota, Metabolic Profiles and Disease Resistance toMicroorganisms · 2025Article
- Rapid visual nucleic acid detection of Vibrio alginolyticus by recombinase polymerase amplification combined with CRISPR/Cas13a.World journal of microbiology & biotechnology · 2023Article
- Exogenous L-Alanine promotes phagocytosis of multidrug-resistant bacterial pathogens.EMBO reports · 2023Article
- Oleic acid as potential immunostimulant in metabolism pathways of hybrid grouper fingerlings (Epinephelus fuscoguttatus × Epinephelus lanceolatus) infected with Vibrio vulnificus.Scientific reports · 2023Article
- Comprehensive insights into the metabolism characteristics of small RNA Qrr4 in Vibrio alginolyticus.Applied microbiology and biotechnology · 2023Article
- Aspartate metabolic flux promotes nitric oxide to eliminate both antibiotic-sensitive and -resistantFrontiers in immunology · 2023Article
- The Importance of Fatty Acid Precision Nutrition: Effects of Dietary Fatty Acid Composition on Growth, Hepatic Metabolite, and Intestinal Microbiota in Marine TeleostAquaculture nutrition · 2023Article
- Integrated Analysis of Transcriptome and Metabolome Reveals Distinct Responses ofInternational journal of molecular sciences · 2022Article
- Nitrite Promotes ROS Production to Potentiate Cefoperazone-Sulbactam-Mediated Elimination to Lab-Evolved and Clinical-Evolved Pseudomonas aeruginosa.Microbiology spectrum · 2022Article
- Article
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- Antibiofilm effect and mechanism of protocatechuic aldehyde againstFrontiers in microbiology · 2022Article
- Glutamine potentiates gentamicin to kill lab-evolved gentamicin-resistant and clinically isolated multidrug-resistantFrontiers in microbiology · 2022Article
- Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Action of Huang Qin Decoction for Treament of Diabetic Liver Injury.Frontiers in pharmacology · 2022Article
- Synergy of alanine and gentamicin to reduce nitric oxide for elevating killing efficacy to antibiotic-resistantVirulence · 2021Article
- Insights into a Pyruvate Sensing and Uptake System inJournal of bacteriology · 2021Article
- Serine Metabolism Tunes Immune Responses To PromotemSystems · 2021Article
- Enhanced Biosynthesis of Fatty Acids Is Associated with the Acquisition of Ciprofloxacin Resistance in Edwardsiella tarda.mSystems · 2021Article
- Activation of the TCA Cycle to Provide Immune Protection in Zebrafish Immunized by High Magnesium-PreparedFrontiers in immunology · 2021Article
- Identification of Polyvalent Vaccine Candidates From Extracellular Secretory Proteins inFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio alginolyticus threatens both humans and marine animals, but hosts respond to V. alginolyticus infection is not fully understood. Here, functional metabolomics was adopted to investigate the metabolic differences between the dying and surviving zebrafish upon V. alginolyticus infection. Tryptophan was identified as the most crucial metabolite, whose abundance was decreased in the dying group but increased in the survival group as compared to control group without infection. Concurrently, the dying zebrafish displayed excessive immune response and produced higher level of reactive oxygen species (ROS). Interestingly, exogenous tryptophan reverted dying rate through metabolome re-programming, thereby enhancing the survival from V. alginolyticus infection. It is preceded by the following mechanism: tryptophan fluxed into the glycolysis and tricarboxylic acid cycle (TCA cycle), promoted adenosine triphosphate (ATP) production and further increased the generation of NADPH. Meanwhile, tryptophan decreased NADPH oxidation. These together ameliorate ROS, key molecules in excessive immune response. This is further supported by the event that the inhibition of pyruvate metabolism and TCA cycle by inhibitors decreased D. reiro survival. Thus, our data indicate that tryptophan is a key metabolite for the host to fight against V. alginolyticus infection, representing an alternative strategy to treat bacterial infection in an antibiotic-independent way.
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