ArticleEMBO reports2020
Suppression of Ca
Open access · bronzeAbstract read
In one paragraph
Article in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- The Caspase-1-EGR4 axis regulates macrophage repolarization in acute myeloid leukemia cells.Scientific reports · 2026Article
- Rewiring tumor immunity via zinc finger proteins: a new frontier in cancer immunotherapy.Journal of translational medicine · 2025Review
- Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review).International journal of molecular medicine · 2025Review
- Early Growth Response Factor 4 (EGR4) Expression in Gut Tissues and Regional Lymph Nodes of Cattle with Different Types of Paratuberculosis-Associated Lesions: Potential Role of EGR4 in Resilience to Paratuberculosis.Animals : an open access journal from MDPI · 2025Article
- BRD4 inhibitor reduces exhaustion and blocks terminal differentiation in CAR-T cells by modulating BATF and EGR1.Biomarker research · 2024Article
- NFYA-mediated promotion of castration-resistant prostate cancer progression through EGR4 regulation.Discover oncology · 2024Article
- Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway.Cell death discovery · 2024Article
- Screening of potential biomarkers in propofol-induced neurotoxicity via bioinformatics prediction and experimental verification.American journal of translational research · 2024Article
- Multifaceted control of T cell differentiation by STIM1.Trends in biochemical sciences · 2023Review
- Article
- Identification of shared characteristics in tumor-infiltrating T cells across 15 cancers.Molecular therapy. Nucleic acids · 2023Article
- The role of mitochondria in the resistance of melanoma to PD-1 inhibitors.Journal of translational medicine · 2023Review
- NETO2 promotes melanoma progression via activation of the CaFrontiers of medicine · 2023Article
- LOF variants identifying candidate genes of laterality defects patients with congenital heart disease.PLoS genetics · 2022Article
- Article
- An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice.Communications biology · 2022Article
- The Role of Calcium Signaling in Melanoma.International journal of molecular sciences · 2022Review
- The Landscape of Early Growth Response Family Members 1-4 in Hepatocellular Carcinoma: Their Biological Roles and Diagnostic Utility.Disease markers · 2022Article
- The function of the calcium channel Orai1 in osteoclast development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Jayati Mookerjee-Basu *Fox Chase Cancer Center, Philadelphia, PA, USA.
Robert Hooper *Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Scott GrossFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Bryant SchultzFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Christina K GoFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Elsie SamakaiFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Jonathan LadnerFox Chase Cancer Center, Philadelphia, PA, USA.
Emmanuelle NicolasFox Chase Cancer Center, Philadelphia, PA, USA.
Yuanyuan TianFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Bo ZhouFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
M Raza ZaidiFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Warren TourtellotteDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, West Hollywood, CA, USA.
Shan HeFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Yi ZhangFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.
Dietmar J KappesFox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0002-9112-509X
Jonathan SoboloffFels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.ORCID 0000-0001-5192-1297
Temple University · USFox Chase Cancer Center · USCedars-Sinai Medical Center · US
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8MSynthetic rescue of antigen-driven T cells and alloimmunityR01AI143256 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A, ZHANG, YI · 2019 to 2023
$2.9MMOLECULAR MECHANISMS MEDIATING NERVE-MUSCLE INTERACTIONSR01NS040748 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOURTELLOTTE, WARREN G · 2001 to 2010
$2.7MDOT1L, reconstitution of plasmacytoid dendritic cells and alloimmunityR01HL154757 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ZHANG, YI · 2021 to 2024
$2.6MEzh2-mediated Epigenetic Effects and AlloimmunityR01HL127351 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ZHANG, YI · 2016 to 2019
$2.4MTranscriptional Control of Th-POK, a Key Regulator of Lineage ControlR01AI068907 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI KAPPES, DIETMAR J · 2008 to 2011
$2.0MPathobiology of Interferon-gamma in UV radiation-induced melanomagenesisR01CA193711 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI ZAIDI, M. RAZA · 2016 to 2020
$1.8MElp1 function in Familial DysautonomiaR01NS095894 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOURTELLOTTE, WARREN G · 2016 to 2019
$1.6MEGR-mediated STIM1-PMCA expression and function in T cell subsetsR01GM117907 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A · 2016 to 2019
$1.6MDissecting the role of ThPOK in thymic development and T cell differentiationR01GM107179 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI KAPPES, DIETMAR J · 2014 to 2017
$1.4MIMMEDIATE EARLY GENE REGULATED DEVELOPMENT/PLASTICITYK02NS046468 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOURTELLOTTE, WARREN G · 2005 to 2009
$785kMentoring and Research in Mouse PathobiologyK26OD010945 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOURTELLOTTE, WARREN G · 2012 to 2014
$471kNCI NIH HHS P30 CA006927NCI NIH HHS R01 CA193711NCRR NIH HHS K26 RR026099NHLBI NIH HHS R01 HL127351NHLBI NIH HHS R01 HL154757NIAID NIH HHS R01 AI068907NIAID NIH HHS R01 AI143256NIAID NIH HHS R56 AI143256NIGMS NIH HHS R01 GM107179NIGMS NIH HHS R01 GM117907NIH HHS K26 OD010945NINDS NIH HHS K02 NS046468NINDS NIH HHS R01 NS040748NINDS NIH HHS R01 NS095894W J Avery Foundation
Abstract
While the zinc finger transcription factors EGR1, EGR2, and EGR3 are recognized as critical for T-cell function, the role of EGR4 remains unstudied. Here, we show that EGR4 is rapidly upregulated upon TCR engagement, serving as a critical "brake" on T-cell activation. Hence, TCR engagement of EGR4
Indexed as
Calcium SignalingEarly Growth Response Transcription FactorsNeoplasmsAnimalsCell DifferentiationLymphocyte ActivationMiceTumor MicroenvironmentZinc FingersEarly Growth Response Transcription FactorsEgr4 protein, mousecancer immunityEGR4K channelsSTIM1Th1 differentiation
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.