ArticleJournal of clinical laboratory analysis2020
Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- hsa_circ_0006156 Suppresses Malignant Progression by Inducing Ferroptosis in Gastric Cancer Via miR-942-5p/NCOA4 Axis.Biochemical genetics · 2026Article
- CircSHPRH inhibits malignancy progression of head and neck squamous cell carcinoma by regulating PI3K/AKT/mTOR signaling pathway.Functional & integrative genomics · 2025Article
- Circular RNAs and immunotherapy in retinoblastoma: emerging biomarkers and precision therapeutic strategies.Frontiers in immunology · 2025Review
- Exploring potential circRNA biomarkers for cancers based on double-line heterogeneous graph representation learning.BMC medical informatics and decision making · 2024Article
- Interplay of circular RNAs in gastric cancer - a systematic review.Frontiers in systems biology · 2024Review
- Genome-wide CRISPR knockout screening identified G protein pathway suppressor 2 as a novel tumor suppressor for uveal melanoma metastasis.Journal of cancer research and clinical oncology · 2023Article
- Circ-SHPRH in human cancers: a systematic review and meta-analysis.Frontiers in cell and developmental biology · 2023Review
- The functional roles of the circRNA/Wnt axis in cancer.Molecular cancer · 2022Review
- Circular RNA regulates the onset and progression of cancer through the mitogen-activated protein kinase signaling pathway.Oncology letters · 2021Review
- Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis.Digestive diseases and sciences · 2021Article
- Clinical value of miR-135 and miR-20a combined with multi-detector computed tomography in the diagnosis of gastric cancer.World journal of surgical oncology · 2021Article
- Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance.Journal of clinical laboratory analysis · 2021Article
- Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression.Cancers · 2021Review
- The Emerging Role of Circ-SHPRH in Cancer.OncoTargets and therapy · 2021Review
- MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers.Diagnostics (Basel, Switzerland) · 2020Review
- Exosomal noncoding RNAs in cholangiocarcinoma: Laboratory noise or hope?World journal of gastrointestinal surgery · 2020Review
- Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric carcinoma (GC) is a familiar carcinoma and serious threat to human health. We investigated the efficacy and mechanism of circular RNA hsa_circ_0001649 on the growth, migration, and invasion of GC cells.
methodsmicroRNA (miR)-20a and hsa_circ_0001649 expression was investigated by RT-qPCR and was changed by cell transfection. CCK-8, flow cytometry, and BrdU assays were, respectively, used to investigate the efficacies of hsa_circ_0001649 and miR-20a on cell viability, apoptosis, and proliferation. Transwell assay was used to investigate the efficacies of hsa_circ_0001649 and miR-20a on cell migration and invasion. Moreover, the levels of cyclin D1, Bax, cleaved caspase-3, and signal pathway-related proteins were investigated by Western blot.
resultsHsa_circ_0001649 was downregulated in GC cells and tissues. Upregulation of hsa_circ_0001649 restrained viability, proliferation, migration, and invasion, while promoted apoptosis. Furthermore, miR-20a was negatively regulated by hsa_circ_0001649 and miR-20a overexpression reversed the efficacy of hsa_circ_0001649 upregulation. Finally, upregulation of hsa_circ_0001649 restrained ERK and Wnt/β-catenin pathways while miR-20a overexpression reversed these progresses.
conclusionUpregulation of hsa_circ_0001649 restrained GC cell growth and metastasis by downregulating miR-20a and thereby inactivated ERK and Wnt/β-catenin pathways.
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Registered trials
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