Evidence map›Paper›PMID 32212229›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Selective Enzymatic Oxidation of Silanes to Silanols.

Susanne Bähr, Sabine Brinkmann-Chen, Marc Garcia-Borràs, John M Roberts, Dimitris E Katsoulis, K N Houk, Frances H Arnold

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Enzymkatalysierte späte Modifizierungen: Besser spät als nie.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  8. Enzymatic Late-Stage Modifications: Better Late Than Never.Angewandte Chemie (International ed. in English) · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Susanne BährDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Blvd, Pasadena, CA, 91125, USA.ORCID 0000-0001-5113-7646
Sabine Brinkmann-ChenDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Blvd, Pasadena, CA, 91125, USA.ORCID 0000-0002-5419-4192
Marc Garcia-BorràsDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-9458-1114
John M RobertsDow Core R&D, 633 Washington Street, Midland, MI, 48674, USA.ORCID 0000-0001-7733-6301
Dimitris E KatsoulisDow Silicones Corporation, 2200 Salzburg Rd, Auburn, MI, 48611, USA.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0002-8387-5261
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Blvd, Pasadena, CA, 91125, USA.ORCID 0000-0002-4027-364X

Funding

Steroselectivity of Synthetically Valuable Enzyme CatalystsR01GM124480 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2018 to 2021
$1.1M
NIGMS NIH HHS R01 GM124480
6 · The paper itself

Abstract

Compared to the biological world's rich chemistry for functionalizing carbon, enzymatic transformations of the heavier homologue silicon are rare. We report that a wild-type cytochrome P450 monooxygenase (P450

Indexed as

Bacillus megateriumBiocatalysisCytochrome P-450 Enzyme SystemModels, MolecularOxidation-ReductionSilanesCytochrome P-450 Enzyme SystemSilanessilanolbiocatalysisdirected evolutionmonooxygenationP450 enzymessilanols

Identifiers

PMID32212229
PMCPMC7511438

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.